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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The evolution of phenotypic integration: How directional selection reshapes covariation in mice

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Author(s):
Penna, Anna [1] ; Melo, Diogo [1] ; Bernardi, Sandra [2] ; Oyarzabal, Maria Ines [3, 4] ; Marroig, Gabriel [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Lab Evolucao Mamiferos, Dept Genet & Biol Evolut, Inst Biociencias, Sao Paulo - Brazil
[2] Univ Nacl Rosario, Fac Ciencias Vet, Catedra Histol & Embriol Basica, Rosario, Santa Fe - Argentina
[3] Univ Nacl Rosario, Fac Ciencias Vet, Catedra Prod Bovinos Carne, Rosario, Santa Fe - Argentina
[4] Univ Nacl Rosario, Consejo Invest, Rosario, Santa Fe - Argentina
Total Affiliations: 4
Document type: Journal article
Source: Evolution; v. 71, n. 10, p. 2370-2380, OCT 2017.
Web of Science Citations: 9
Abstract

Variation is the basis for evolution, and understanding how variation can evolve is a central question in biology. In complex phenotypes, covariation plays an even more important role, as genetic associations between traits can bias and alter evolutionary change. Covariation can be shaped by complex interactions between loci, and this genetic architecture can also change during evolution. In this article, we analyzed mouse lines experimentally selected for changes in size to address the question of how multivariate covariation changes under directional selection, as well as to identify the consequences of these changes to evolution. Selected lines showed a clear restructuring of covariation in their cranium and, instead of depleting their size variation, these lines increased their magnitude of integration and the proportion of variation associated with the direction of selection. This result is compatible with recent theoretical works on the evolution of covariation that take the complexities of genetic architecture into account. This result also contradicts the traditional view of the effects of selection on available covariation and suggests a much more complex view of how populations respond to selection. (AU)

FAPESP's process: 11/14295-7 - Modularity and its evolutionary consequences
Grantee:Gabriel Henrique Marroig Zambonato
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/06577-8 - Morphologic Integration in Lemuriform (Primates: Strepsirrhini) Skull.
Grantee:Anna Paula Casselli Penna
Support type: Scholarships in Brazil - Master
FAPESP's process: 14/26262-4 - Direct estimates of evolutionary parameters via quantitative trait loci analysis
Grantee:Diogo Amaral Reboucas Melo
Support type: Scholarships in Brazil - Doctorate