Bone turnover after bariatric surgery

Autor(es)

Melo, Thalita Lima ^[1] ; Froeder, Leila ^[1] ; Baia, Leandro da Cunha ^[1] ; Heilberg, Ita Pfeferman ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo Unifesp, Disciplina Nefrol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 61, n. 4, p. 332-336, JUL-AUG 2017.
• Citações Web of Science: 2

Resumo

ABSTRACT Objective The aim of the present study was to evaluate parameters of bone and mineral metabolism after bariatric surgery. Subjects and methods This sectional study included data from medical records from 61 bariatric surgery (BS) patients (minimum period of 6 months after the procedure) and from 30 class II and III obese patients as a control group (Cont), consisting of daily dietary intake of macronutrients, calcium and sodium, serum 25(OH)D and parathyroid hormone (PTH) and other biochemical serum and urinary parameters. Bone alkaline phosphatase (BAP), leptin, fibroblast growth factor-23 (FGF-23) and deoxypyridinoline (DPYD) were determined from available banked serum and urinary samples. Results Mean body mass index (BMI), median energy, carbohydrate, protein and sodium chloride consumption were significantly lower in the BS versus Cont, but calcium and lipids were not. No significant differences were found in ionized calcium, 25(OH)D, PTH and fibroblast growth factor 23 (FGF-23) between groups. Mean serum BAP was significantly higher for BS versus Cont and had a positive correlation with time after the surgical procedure. Mean serum leptin was significantly lower and median urinary DPYD higher in BS versus Cont. Conclusion The present study showed an increase in bone markers of both bone formation and resorption among bariatric patients up to more than 7 years after the surgical procedure, suggesting that an increased bone turnover persists even at a very long-term follow-up in such patients. (AU)

• Processo FAPESP: 08/02279-4 - Avaliação dos fatores de risco para Litíase Renal no pós-operatório tardio de cirurgia bariátrica
• Beneficiário: Leila Froeder
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto