The effect of coffee intake on lysophosphatidylcholines: A targeted metabolomic approach

Autor(es)

Miranda, Andreia Machado ^[1] ; Ferreira Carioca, Antonio Augusto ^[1] ; Steluti, Josiane ^[1] ; Cotrim Guerreiro da Silva, Ismael Dale ^[2] ; Fisberg, Regina Mara ^[1] ; Marchioni, Dirce Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Gynecol, Paulista Sch Med, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical Nutrition; v. 36, n. 6, p. 1635-1641, DEC 2017.
• Citações Web of Science: 1

Resumo

Background \& aim: Lysophosphatidylcholines (lysoPC) are known to be a pathological component of oxidized-LDL, and several studies demonstrate its pro-inflammatory properties in vitro. Nevertheless, bioactive compounds found in coffee, such as phenolic acids might inhibit LDL oxidation. The relationship between coffee consumption and lysoPC has not been described previously in humans. The aim of the present study was to assess the association between coffee intake and plasma lysoPC levels in adults. Methods: Data was from the ``Health Survey of Sao Paulo (ISA-Capital){''}, a cross-sectional population based survey in Sao Paulo, among 169 individuals aged 20 years or older. This population was categorized into three groups: non-coffee consumers (0 mL/day-G1), low coffee consumers (<= 100 mL/day-G2), and high coffee consumers (>100 mLiday-G3). Usual coffee intake was estimated by two 24HR and one FFQ using Multiple Source Method. Quantification of the metabolites was performed by mass spectrometry (FIA-MS/MS and HPLC-MS/MS) and 14 lysoPC species were identified. The association between coffee intake and lysoPC was analyzed by multiple linear regression adjusted for age, sex, household per capita income, smoking, physical activity, body mass index, total energy intake, use of drugs, vegetables and fruit consumption and caffeine intake. Results: LysoPC levels were significantly lower in G3 than in Gl, for the lysoPC a C16:1 ((beta = -0.56; p = 0.014), lysoPC a C18:1 (beta = -2.57; p = 0.018), and lysoPC a C20:4 (beta = -1.14; p = 0.037). In opposition, the ratios of C16:0/C16:1 and C18:0/18:1 was higher in G3 (beta= 5.04; p = 0.025 and beta = 0.28; p = 0.003, respectively). Conclusion: LysoPC profile differed according to coffee intake, showing a possible beneficial health effect of this beverage on inflammatory and oxidative processes. 2016 Published by Elsevier Ltd. (AU)

• Processo FAPESP: 14/04540-2 - Estudo epidemiológico do consumo do café, sua contribuição na ingestão de polifenóis e seus potenciais efeitos nos fatores de risco cardiovascular, considerando variações genéticas individuais
• Beneficiário: Andreia Alexandra Machado Miranda
• Modalidade de apoio: Bolsas no Brasil - Doutorado