The effect of coffee intake on lysophosphatidylcholines: A targeted metabolomic approach

Author(s)

Miranda, Andreia Machado ^[1] ; Ferreira Carioca, Antonio Augusto ^[1] ; Steluti, Josiane ^[1] ; Cotrim Guerreiro da Silva, Ismael Dale ^[2] ; Fisberg, Regina Mara ^[1] ; Marchioni, Dirce Maria ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Gynecol, Paulista Sch Med, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Clinical Nutrition; v. 36, n. 6, p. 1635-1641, DEC 2017.
• Web of Science Citations: 1

Abstract

Background \& aim: Lysophosphatidylcholines (lysoPC) are known to be a pathological component of oxidized-LDL, and several studies demonstrate its pro-inflammatory properties in vitro. Nevertheless, bioactive compounds found in coffee, such as phenolic acids might inhibit LDL oxidation. The relationship between coffee consumption and lysoPC has not been described previously in humans. The aim of the present study was to assess the association between coffee intake and plasma lysoPC levels in adults. Methods: Data was from the ``Health Survey of Sao Paulo (ISA-Capital){''}, a cross-sectional population based survey in Sao Paulo, among 169 individuals aged 20 years or older. This population was categorized into three groups: non-coffee consumers (0 mL/day-G1), low coffee consumers (<= 100 mL/day-G2), and high coffee consumers (>100 mLiday-G3). Usual coffee intake was estimated by two 24HR and one FFQ using Multiple Source Method. Quantification of the metabolites was performed by mass spectrometry (FIA-MS/MS and HPLC-MS/MS) and 14 lysoPC species were identified. The association between coffee intake and lysoPC was analyzed by multiple linear regression adjusted for age, sex, household per capita income, smoking, physical activity, body mass index, total energy intake, use of drugs, vegetables and fruit consumption and caffeine intake. Results: LysoPC levels were significantly lower in G3 than in Gl, for the lysoPC a C16:1 ((beta = -0.56; p = 0.014), lysoPC a C18:1 (beta = -2.57; p = 0.018), and lysoPC a C20:4 (beta = -1.14; p = 0.037). In opposition, the ratios of C16:0/C16:1 and C18:0/18:1 was higher in G3 (beta= 5.04; p = 0.025 and beta = 0.28; p = 0.003, respectively). Conclusion: LysoPC profile differed according to coffee intake, showing a possible beneficial health effect of this beverage on inflammatory and oxidative processes. 2016 Published by Elsevier Ltd. (AU)

• FAPESP's process: 14/04540-2 - Epidemiological study of coffee consumption, its contribution for polyphenols intake and potential effects on cardiovascular risk factors, considering individual genetic variations
• Grantee: Andreia Alexandra Machado Miranda
• Support Opportunities: Scholarships in Brazil - Doctorate