Clarithromycin as an Adjunct to One-Stage Full-Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Trial

Autor(es)

Rebelatto Bechara Andere, Naira Maria ^[1] ; Castro dos Santos, Nidia Cristina ^[1] ; Araujo, Cassia Fernandes ^[1] ; Mathias, Ingrid Fernandes ^[1] ; Taiete, Tiago ^[2] ; Viana Casarin, Renato Correa ^[2] ; Neves Jardini, Maria Aparecida ^[1] ; Shaddox, Luciana Machion ^[3] ; Santamaria, Mauro Pedrine ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Div Periodontol, Dept Diag & Surg, Coll Dent, Sao Jose Dos Campos - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Div Periodont, Dept Prosthodont & Periodont, Piracicaba - Brazil

^[3] Univ Florida, Coll Dent, Dept Periodontol & Oral Biol, Gainesville, FL - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of Periodontology; v. 88, n. 12, p. 1244-1252, DEC 2017.
• Citações Web of Science: 4

Resumo

Background: The aim of the present study is to evaluate the periodontal clinical and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. Methods: Forty patients were selected and randomly assigned into one of two groups: 1) CLM (n = 20): one-stage full-mouth ultrasonic debridement (FMUD) associated with CLM (500 mg, every 12 hours for 3 days); and 2) placebo (n = 20): FMUD associated with placebo pills. Clinical and microbiologic parameters were evaluated at baseline and 3 and 6 months postoperatively. Results: Both treatments presented statistically significant clinical and microbiologic improvements. However, the CLM group presented lower means of probing depth for pockets >7 mm at 6 months (4.0 +/- 1.7 mm) compared with the placebo group (4.7 +/- 1.3 mm) (P = 0.04). In addition, the CLM group also presented greater reduction of Porphyromonas gingivalis (Pg) DNA counts at 6 months (P = 0.0001). Conclusion: Results from this study suggest both treatments are effective; however, adjunct use of CLM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone. (AU)

• Processo FAPESP: 15/12669-8 - Avaliação do efeito local do tratamento periodontal não-cirúrgico associado ou não à administração de antibiótico sistêmico e à terapia fotodinâmica no tratamento de pacientes com periodontitite agressiva generalizada: estudo randomizado
• Beneficiário: Renata Silveira Sagnori
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 15/04621-5 - Claritromicina como adjuvante ao debridamento periodontal no tratamento de periodontite agressiva generalizada: Estudo randomizado.
• Beneficiário: Tamires Pereira Dutra
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica