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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Morphological changes in rat rectus abdominis muscle induced by diabetes and pregnancy

Texto completo
Autor(es):
G. Vesentini [1] ; G. Marini [1, 2] ; F. Piculo [1] ; D.C. Damasceno [1] ; S.M.M. Matheus [3] ; S.L. Felisbino [4] ; I.M.P. Calderon [1] ; A. Hijaz [5] ; A.M.P. Barbosa [6] ; M.V.C. Rudge [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Fac Med Botucatu, Dept Ginecol & Obstet, Botucatu, SP - Brazil
[2] Univ Sagrado Coracao, Dept Ciencias Saude, Sagrado, SP - Brazil
[3] Univ Estadual Paulista, Inst Biociencias Botucatu, Dept Anat, Botucatu, SP - Brazil
[4] Univ Estadual Paulista, Inst Biociencias Botucatu, Dept Morfol, Botucatu, SP - Brazil
[5] Univ Hosp Case Med Ctr, Urol Inst, Dept Urol, Cleveland, OH - USA
[6] Univ Estadual Paulista, Dept Fisioterapia & Terapia Ocupac, Botucatu, SP - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Medical and Biological Research; v. 51, n. 4 2018-03-01.
Resumo

The urethral muscle of diabetic pregnant rats is affected by long-term mild diabetes and short-term severe diabetes, which plays a crucial role in the pathogenesis of pelvic floor disorders. We hypothesized that muscles outside the pelvis are subject to similar changes. The current study aimed at analyzing the effects of long-term mild and short-term severe diabetes on the structure and ultrastructure of fiber muscles and collagen in rats' rectus abdominis (RA) muscle. Therefore, the RA muscle of virgin, pregnant, long-term mild diabetic, short-term severe diabetic, long-term mild diabetic pregnant and short-term severe diabetic pregnant 3-month-old Wistar rats were collected. The structure was analyzed by picrosirius red staining, immunohistochemistry for fast and slow muscle fibers and transmission electron microscopy. We investigated two levels of STZ- induced diabetes: long-term mild diabetes (blood glucose level: 120–200 mg/dL) and short-term severe diabetes (blood glucose level >300 mg/dL). Long-term mild diabetic pregnant and short-term severe diabetic pregnant rats had decreased fast fibers and increased slow fibers, disrupted areas of sarcomere, intermyofibrillar mitochondria and myelin figures in the RA muscle. Both groups enabled us to analyze the specific influence of pregnancy, separately from diabetes. The current study demonstrated that diabetes and pregnancy induced intramuscular transformation and reorganization of RA muscle with a switch of fiber type adjusting their architecture according to intensity and duration of hyperglycemic insult within pregnancy. (AU)

Processo FAPESP: 12/25053-7 - Análise morfológica do músculo reto abdominal de ratas prenhes diabéticas
Beneficiário:Giovana Vesentini
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/14144-7 - Análise da matriz extracelular do músculo reto abdominal de ratas prenhes diabéticas
Beneficiário:Giovana Vesentini
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado