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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Is surgical debridement necessary in the diabetic foot treated with photodynamic therapy?

Texto completo
Autor(es):
Tardivo, Joao Paulo [1] ; Serrano, Rodrigo [1] ; Zimmermann, Livia Maria [1] ; Matos, Leandro Luongo [2] ; Baptista, Mauricio S. [3] ; Silva Pinhal, Maria Aparecida [3] ; Atallah, Alvaro N. [4]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Hosp Anchieta, Fac Med ABC, Sao Bernardo Do Campo - Brazil
[2] Fac Med ABC, Dept Bioquim, Santo Andre - Brazil
[3] Univ Sao Paulo, Dept Bioquim, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Med, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: DIABETIC FOOT & ANKLE; v. 8, n. 1 SEP 19 2017.
Citações Web of Science: 2
Resumo

Background: Diabetic patients are susceptible to developing foot ulcerswith serious complications such as osteomyelitis and amputations. Treatment approaches are still empirical and the benefit of usual procedures such as surgical debridement has not been properly evaluated. Photodynamic Therapy (PDT) is a non-invasive and highly efficient method for the treatment of the diabetic foot, being able to eradicate the infection and to stimulate healing, decreasing considerably the amputation risk. In the day-to-day practice of our service, we have been faced with the question whether debridement is necessary before PDT. In here, we designed a study to answer that question. Methods: Patients were divided in two groups: In one of the groups (n = 17), debridement was performed before PDT and in the other (n = 40) only PDT treatment was performed. PDT sessions were performed once a week in all patients until healing was achieved, as indicated by visual inspection as well as by radiographic and laboratory exams. At the start of the study, the two groups had no statistical differences concerning their clinical features: average age, gender, insulin use, diabetes mellitus onset time and previous amputations. Results: PDT was effective in the treatment of 100% of the patients showing no relapses after one year of follow up. The group submitted to PDT without previous debridement had a statistically significant (p = 0.036, Mann-Whitney) shorter cure time (29 days, similar to 27%). Conclusion: Our data indicates that debridement is not necessary in the treatment of diabetic foot in patients that have enough peripheral arterial perfusion. In addition, we reproduced previous studies confirming that PDT is an efficient, safe, simple and affordable treatment method for the diabetic foot. (AU)

Processo FAPESP: 13/07937-8 - Redoxoma
Beneficiário:Ohara Augusto
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 12/50680-5 - Fotossensibilização nas ciências da vida
Beneficiário:Mauricio da Silva Baptista
Linha de fomento: Auxílio à Pesquisa - Temático