Is cerebral microbleed prevalence relevant as a biomarker in amnestic mild cognitive impairment and mild Alzheimer's disease?

Autor(es):Mostrar menos -

Rabelo, Ana G. B. ^[1] ; Teixeira, Camila V. L. ^{[1, 2]} ; Magalhaes, Thamires N. C. ^{[1, 2]} ; Carletti-Cassani, Ana Flavia M. K. ^[1] ; Amato Filho, Augusto C. S. ^[3] ; Joaquim, Helena P. G. ^[4] ; Talib, Leda L. ^[4] ; Forlenza, Orestes ^[4] ; Ribeiro, Patricia A. O. ^{[5, 2]} ; Secolin, Rodrigo ^{[5, 2]} ; Lopes-Cendes, Iscia ^{[5, 2]} ; Cendes, Fernando ^{[1, 2]} ; Balthazar, Marcio L. F. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, NeuroImage Lab, Rua Vital Brazil, 251 Cidade Univ Zeferino Vaz, Campinas, SP - Brazil

^[2] Brazilian Inst Neurosci & Neurotechnol BRAINN, Sao Paulo - Brazil

^[3] Univ Estadual Campinas, Dept Radiol, Campinas, SP - Brazil

^[4] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Lab Neurociencias LIM27, Dept & Inst Psiquiat, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Dept Med Genet, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEURORADIOLOGY JOURNAL; v. 30, n. 5, p. 477-485, OCT 2017.
• Citações Web of Science: 2

Resumo

Introduction: The search for a reliable neuroimaging biomarker in Alzheimer's disease is a matter of intense research. The presence of cerebral microbleeds seems to be a potential biomarker. However, it is not clear if the presence of microbleeds has clinical usefulness to differentiate mild Alzheimer's disease and amnestic mild cognitive impairment from normal aging. We aimed to verify if microbleed prevalence differs among three groups: mild Alzheimer's disease, amnestic mild cognitive impairment due to Alzheimer's disease, and normal controls. Moreover, we studied whether microbleeds were associated with apolipoprotein E allele epsilon 4 status, cerebrospinal fluid amyloid-beta, total and phosphorylated tau protein levels, vascular factors, and cognition. Methods: Twenty-eight mild Alzheimer's disease patients, 34 with amnestic mild cognitive impairment and 36 cognitively normal elderly subjects underwent: magnetic resonance imaging with a susceptibility-weighted imaging sequence on a 3T scanner, apolipoprotein E genotyping and a full neuropsychological evaluation. Only amnestic mild cognitive impairment and mild Alzheimer's disease underwent cerebrospinal fluid analysis. We compared the groups and verified if microbleeds were predicted by all other variables. Results: Mild Alzheimer's disease presented a higher prevalence of apolipoprotein E allele epsilon 4 in relation to amnestic mild cognitive impairment and control group. No significant differences were found between groups when considering microbleed presence. Logistic regression tests failed to find any relationship between microbleeds and the variables. We performed three different regression models using different independent variables: Model 1 - amyloid-beta, phosphorylated tau protein, total tau, apolipoprotein E allele epsilon 4 status, age, and sex; Model 2 - vascular risk factors, age, and sex; Model 3 cognitive scores sex, age, and education. Conclusion: Although microbleeds might be related to the Alzheimer's disease process, their presence is not a good candidate for a neuroimaging biomarker of the disease, especially in its early phases. (AU)

• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/25429-2 - Associação entre microssangramentos lobares, níveis de beta-amilóide liquórico e alelo epsilon-4 do gene APOE em pacientes com demência na Doença de Alzheimer e comprometimento cognitivo leve
• Beneficiário: Ana Gabriela Bicalho Rabelo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica