Synthesis, Characterization and Biological Activities of Biopolymeric Schiff Bases Prepared with Chitosan and Salicylaldehydes and Their Pd(II) and Pt(II) Complexes

Autor(es)

Goncalves Barbosa, Hellen Franciane ^[1] ; Attjioui, Maha ^[2] ; Garcia Ferreira, Ana Paula ^[1] ; Dockal, Edward Ralph ^[3] ; El Gueddari, Nour Eddine ^[2] ; Moerschbacher, Bruno M. ^[2] ; Gomes Cavalheiro, Eder Tadeu ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim Sao Carlos, Av Trabalhador Sao Carlense 400, BR-13566590 Sao Carlos, SP - Brazil

^[2] Westfalische Wilhelms Univ Munster, Inst Plant Biol & Biotechnol IBBP, Schlosspl 8, D-48143 Munster - Germany

^[3] Univ Fed Sao Carlos, Dept Quim, Via Washington Luis, Km 235, BR-13560900 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 22, n. 11 NOV 2017.
• Citações Web of Science: 7

Resumo

In an attempt to enhance chitosan biological activities, biopolymeric Schiff bases of chitosan and different salicylaldehydes and their palladium(II) and platinum(II) complexes were synthesized and tested. The chemical structures of these derivatives were characterized using H-1-NMR, FTIR spectroscopy and XPRD. Thermal analysis was done through TGA/DTG-DTA. Electronic absorption spectra and surface morphologies were analyzed by SEM-EDAX. Chitosan and its derivatives were evaluated for their in vitro antimicrobial activity against two common bacterial and fungal plant pathogens Pseudomonas syringae pv. tomato and Fusarium graminearum, respectively, and for their antitumor activity against a human breast cancer cell line (MCF-7). It was found that, compared to the nonmodified chitosan, chitosan modified with Schiff bases and their complexes was highly toxic against the MCF-7 cell line and had antibacterial effects against P. syringea. However, the modified chitosan derivatives had less pronounced antifungal effects against F. graminearum compared to the nonmodified chitosan, suggesting different modes of action. (AU)