Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

(Pro)renin receptor expression in myocardial infarction in transgenic mice expressing rat tonin

Texto completo
Autor(es):
Ribeiro, Amanda A. [1] ; Amorim, Rebeca Padrao [2] ; Palomino, Zaira J. [1] ; Lima, Mercia de Paula [3] ; Moraes-Silva, Ivana Cinthya [4] ; Souza, Leandro Ezequiel [4] ; Pesquero, Jorge Luiz [3] ; Irigoyen, Maria Claudia [4] ; Casarini, Dulce E. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Nephrol Div, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, Expt Neurol Div, Sao Paulo, SP - Brazil
[3] Univ Fed Minas Gerais, Dept Biophis, Belo Horizonte, MG - Brazil
[4] Univ Sao Paulo, Heart Inst, Dept Hpertens, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: International Journal of Biological Macromolecules; v. 108, p. 817-825, MAR 2018.
Citações Web of Science: 5
Resumo

The (pro)renin receptor {[}(P)RR] has been implicated as a renin/prorenin receptor, and plays a role in local renin angiotensin system activation. Our goal was to investigate whether a transgenic mouse that expresses rat tonin {[}TGM'(rTon)] can regulate (P)RR mRNA levels. Control (C) and TGM'(rTon) animals were subdivided into the C sham, C MI, TGM'(rTon) sham, and TGM'(rTon) MI groups. The levels of tonin, (P)RR, and renin were determined using RT-PCR mRNA. Tonin activity as determined by RIE was significantly increased in the TGM'(rTon) sham group as compared to the C sham group in the atrium (AT) and right ventricle (RV), respectively. In most mice, tonin mRNA levels were significantly reduced compared to those in the TGM'(rTon) sham group in the atria. In this structure, the (P)RR mRNA levels were statistically significantly reduced in the TGM'(rTon) sham and TGM'(rTon) MI groups compared to the control groups. However, the (P)RR mRNA values were significantly increased when we compared the TGM'(rTon) MI vs TGM'(rTon) sham groups. In the RV, the renin mRNA levels in the TGM'(rTon) sham group were significantly reduced compared to the C sham group. Tonin overexpression may act in the regulation of (P)RR mRNA levels during MI. (C) 2017 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 10/19989-4 - O papel do receptor da pró-renina no infarto agudo do miocárdio no camundongo transgênico que expressa tonina de rato
Beneficiário:Amanda Aparecida Ribeiro
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 10/51904-9 - Sistema renina angiotensina e calicreina cininas na hipertensão, obesidade, diabetes, desnutrição e sepses: mecanismos moleculares, celulares e fisiopatológicos
Beneficiário:Dulce Elena Casarini
Linha de fomento: Auxílio à Pesquisa - Temático