Immunoexpression of proteins involved in cytoskeleton remodeling in benign odontogenic lesions

Autor(es)

Antonio, Paula Nascimento ^[1] ; Garcia, Natalia Galvao ^[1] ; Assao, Agnes ^[1] ; Pereira Lauris, Jose Roberto ^[2] ; Soares, Fernando Augusto ^[3] ; Oliveira, Denise Tostes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, Al Dr Octavio Pinheiro Brisolla 9-75, BR-17120901 Bauru, SP - Brazil

^[2] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, Al Dr Octavio Pinheiro Brisolla 9-75, BR-17120901 Bauru, SP - Brazil

^[3] AC Camargo Canc Hosp, Dept Pathol, R Prof Antonio Prudente 211, BR-01509010 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 87, p. 151-156, MAR 2018.
• Citações Web of Science: 1

Resumo

Objective: The present study was designed to analyze the immunolocalization of proteins involved in cytoskeleton remodeling, such as moesin and Rho-A, in benign odontogenic lesions that present with expansive growth and invasive clinical behavior. Materials and methods: Expressions of moesin and Rho-A in odontogenic epithelium were evaluated by immunohistochemical analysis in 45 odontogenic lesions using monoclonal antibodies. Results: Our results demonstrated strong membranous and cytoplasmic expressions of moesin in the epithelial cells in 66.7% and 44.4% of the odontogenic lesions, respectively. Furthermore, Rho-A expression in odontogenic epithelium was strong in the membrane and cytoplasm of 51.1% and 62.2% of the odontogenic lesions, respectively. A statistically significant correlation was found between the membranous and cytoplasmic expressions of moesin (p = 0.000) and those of Rho-A (p = 0.048) in odontogenic epithelial cells, while no statistically significant correlation was found between moesin and Rho-A expressions (p > 0.05). Conclusions: The present study confirmed the strong expressions of moesin and Rho-A by odontogenic epithelial cells, suggesting their involvement in the development of benign odontogenic lesions. However, this study has failed to detect the connection between the moesin and Rho-A interaction in expansive growth and local invasiveness of these lesions. (AU)

• Processo FAPESP: 12/13411-6 - Participação da podoplanina no processo de remodelação celular em tumores odontogênicos benignos e tumores epiteliais malignos de boca
• Beneficiário: Denise Tostes Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular