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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunoexpression of proteins involved in cytoskeleton remodeling in benign odontogenic lesions

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Author(s):
Antonio, Paula Nascimento [1] ; Garcia, Natalia Galvao [1] ; Assao, Agnes [1] ; Pereira Lauris, Jose Roberto [2] ; Soares, Fernando Augusto [3] ; Oliveira, Denise Tostes [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, Al Dr Octavio Pinheiro Brisolla 9-75, BR-17120901 Bauru, SP - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, Al Dr Octavio Pinheiro Brisolla 9-75, BR-17120901 Bauru, SP - Brazil
[3] AC Camargo Canc Hosp, Dept Pathol, R Prof Antonio Prudente 211, BR-01509010 Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 87, p. 151-156, MAR 2018.
Web of Science Citations: 1
Abstract

Objective: The present study was designed to analyze the immunolocalization of proteins involved in cytoskeleton remodeling, such as moesin and Rho-A, in benign odontogenic lesions that present with expansive growth and invasive clinical behavior. Materials and methods: Expressions of moesin and Rho-A in odontogenic epithelium were evaluated by immunohistochemical analysis in 45 odontogenic lesions using monoclonal antibodies. Results: Our results demonstrated strong membranous and cytoplasmic expressions of moesin in the epithelial cells in 66.7% and 44.4% of the odontogenic lesions, respectively. Furthermore, Rho-A expression in odontogenic epithelium was strong in the membrane and cytoplasm of 51.1% and 62.2% of the odontogenic lesions, respectively. A statistically significant correlation was found between the membranous and cytoplasmic expressions of moesin (p = 0.000) and those of Rho-A (p = 0.048) in odontogenic epithelial cells, while no statistically significant correlation was found between moesin and Rho-A expressions (p > 0.05). Conclusions: The present study confirmed the strong expressions of moesin and Rho-A by odontogenic epithelial cells, suggesting their involvement in the development of benign odontogenic lesions. However, this study has failed to detect the connection between the moesin and Rho-A interaction in expansive growth and local invasiveness of these lesions. (AU)

FAPESP's process: 12/13411-6 - The role of podoplanin in the process of cellular remodelling in benign odontogenic tumors and oral malignant epithelial tumors
Grantee:Denise Tostes Oliveira
Support Opportunities: Regular Research Grants