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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Maternal metabolic adaptations are necessary for normal offspring growth and brain development

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Autor(es):
Ramos-Lobo, Angela M. [1] ; Furigo, Isadora C. [1] ; Teixeira, Pryscila D. S. [1] ; Zampieri, Thais T. [1] ; Wasinski, Frederick [1] ; Buonfiglio, Daniella C. [1] ; Donato, Jr., Jose [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: PHYSIOLOGICAL REPORTS; v. 6, n. 5 MAR 2018.
Citações Web of Science: 3
Resumo

Several metabolic adaptations emerge during pregnancy and continue through lactation, including increases in food intake and body weight, as well as insulin and leptin resistance. These maternal adaptations are thought to play a role in offspring viability and success. Using a model of attenuated maternal metabolic adaptations induced by ablation of the Socs3 gene in leptin receptor expressing cells (SOCS3 KO mice), our study aimed to investigate whether maternal metabolic changes are required for normal offspring development, and if their absence causes metabolic imbalances in adulthood. The litters were subjected to a cross-fostering experimental design to distinguish the prenatal and postnatal effects caused by maternal metabolic adaptations. Males either born or raised by SOCS3 KO mice showed reduced body weight until 8weeks of life. Both adult males and females born or raised by SOCS3 KO mice also had lower body adiposity. Despite that, no significant changes in energy expenditure, glucose tolerance or insulin resistance were observed. However, males either born or raised by SOCS3 KO mice showed reduced brain mass in adulthood. Furthermore, animals born from SOCS3 KO mice also had lower proopiomelanocortin fiber density in the paraventricular nucleus of the hypothalamus. In conclusion, these findings indicate that the commonly observed metabolic changes in pregnancy and lactation are necessary for normal offspring growth and brain development. (AU)

Processo FAPESP: 16/20897-3 - Papel dos neurônios orexina como mediadores dos efeitos centrais induzidos pelo hormônio do crescimento
Beneficiário:Frederick Wasinski
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/10992-6 - Estudo da programação metabólica por meio de diferentes abordagens
Beneficiário:Jose Donato Junior
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/15517-6 - Fatores moleculares envolvidos nas alterações metabólicas durante a gestação: papel do SOCS3
Beneficiário:Thais Tessari Zampieri
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 14/11752-6 - Estudo das funções da leptina durante o período intrauterino e infância no camundongo
Beneficiário:Angela Maria Ramos Lobo
Linha de fomento: Bolsas no Brasil - Doutorado