| Full text | |
| Author(s): |
Ramos-Lobo, Angela M.
[1]
;
Furigo, Isadora C.
[1]
;
Teixeira, Pryscila D. S.
[1]
;
Zampieri, Thais T.
[1]
;
Wasinski, Frederick
[1]
;
Buonfiglio, Daniella C.
[1]
;
Donato, Jr., Jose
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | PHYSIOLOGICAL REPORTS; v. 6, n. 5 MAR 2018. |
| Web of Science Citations: | 4 |
| Abstract | |
Several metabolic adaptations emerge during pregnancy and continue through lactation, including increases in food intake and body weight, as well as insulin and leptin resistance. These maternal adaptations are thought to play a role in offspring viability and success. Using a model of attenuated maternal metabolic adaptations induced by ablation of the Socs3 gene in leptin receptor expressing cells (SOCS3 KO mice), our study aimed to investigate whether maternal metabolic changes are required for normal offspring development, and if their absence causes metabolic imbalances in adulthood. The litters were subjected to a cross-fostering experimental design to distinguish the prenatal and postnatal effects caused by maternal metabolic adaptations. Males either born or raised by SOCS3 KO mice showed reduced body weight until 8weeks of life. Both adult males and females born or raised by SOCS3 KO mice also had lower body adiposity. Despite that, no significant changes in energy expenditure, glucose tolerance or insulin resistance were observed. However, males either born or raised by SOCS3 KO mice showed reduced brain mass in adulthood. Furthermore, animals born from SOCS3 KO mice also had lower proopiomelanocortin fiber density in the paraventricular nucleus of the hypothalamus. In conclusion, these findings indicate that the commonly observed metabolic changes in pregnancy and lactation are necessary for normal offspring growth and brain development. (AU) | |
| FAPESP's process: | 16/20897-3 - Role of orexin neurons as mediators of the central effects induced by growth hormone |
| Grantee: | Frederick Wasinski |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 12/15517-6 - Involvment of molecular factors in metabolic changes during pregnancy: role of SOCS3 |
| Grantee: | Thais Tessari Zampieri |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/10992-6 - Investigation of metabolic programming through different approaches |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice |
| Grantee: | Angela Maria Ramos Lobo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |