It has been demonstrated that adverse environmental factors in prenatal period can disrupt the normal pattern of fetal growth and development, leading to a phenotype more susceptible to diseases, such as hypertension, glucose intolerance, insulin resistance, hyperlipidemia, hyperinsulinemia, obesity, chronic obstructive pulmonary disease, in adulthood. In fact, failure of the maternal-placental supply to match fetal nutrient demand results in a range of fetal adaptations and developmental changes. Although these adaptations may be beneficial for short-term survival, they can lead to permanent alterations in body structure and metabolism and thereby to cardiovascular and metabolic diseases in adult life. In previous works, our group demonstrated that global intrauterine undernutrition caused hypocellularity in bone marrow and peripheral blood, in Wistar rats. Besides, the reduction in adhesion molecules expression, in collagen (extracellular matrix), and the generation of inflammatory mediators caused a reduction in leukocyte migration, in these rats. In this model, we also observed reduction in lung allergic inflammation induced by ovalbumin. However, in this situation, this response was age-dependent. Considering the epigenetic mechanisms are crucial for chromatin structure reprogramming and gene expression during development and cell differentiation, we hypothesized that molecular mechanisms, including epigenetic alterations due to global undernutrition throughout the gestational period might be involved in the mechanisms of the attenuation of inflammatory response, acute and lung allergic, observed in Wistar rats. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA, TIAGO JANUARIO;
COLLI, LUCAS GIGLIO;
LANDGRAF, MARISTELLA ALMEIDA;
RODRIGUES, STEPHEN FERNANDES;
PINHO FRANCO, MARIA DO CARMO;
LANDGRAF, RICHARDT GAMA;
SANTOS-EICHLER, ROSANGELA APARECIDA;
BOMFIM, GISELE FACHOLI;
AKAMINE, ELIANA HIROMI;
CATELLI DE CARVALHO, MARIA HELENA.
Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension.
Web of Science Citations: 2.