Mechanisms involved in reduced acute and allergic lung inflammation in rats exposed to intrauterine undernourishment.

• Grant number: 12/51104-8
• Support Opportunities: Research Grants - Young Investigators Grants
• Duration: May 01, 2013 - April 30, 2018
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Maristella de Almeida Vitta Landgraf
• Grantee: Maristella de Almeida Vitta Landgraf
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 15/23026-0 - Involvement of global methylation in the development of lung allergic inflammation, in intrauterine undernourished rats, at different ages, BP.MS; 15/22674-9 - Involvement of global methylation in the development of pulmonary allergic inflammation in malnourished rats during prenatal period at different ages, BP.IC; 14/01266-7 - Involvement of glucocorticoids in acute pulmonary inflammation induced by lipopolysaccharide (LPS) in malnourished rats during the gestational period at different ages, BP.IC; 13/09240-4 - Molecular mechanisms involved in reduction of the acte and allergic lung inflammatory response, in rats submitted to intrauterine undernutrition, BP.JP

Abstract

It has been demonstrated that adverse environmental factors in prenatal period can disrupt the normal pattern of fetal growth and development, leading to a phenotype more susceptible to diseases, such as hypertension, glucose intolerance, insulin resistance, hyperlipidemia, hyperinsulinemia, obesity, chronic obstructive pulmonary disease, in adulthood. In fact, failure of the maternal-placental supply to match fetal nutrient demand results in a range of fetal adaptations and developmental changes. Although these adaptations may be beneficial for short-term survival, they can lead to permanent alterations in body structure and metabolism and thereby to cardiovascular and metabolic diseases in adult life. In previous works, our group demonstrated that global intrauterine undernutrition caused hypocellularity in bone marrow and peripheral blood, in Wistar rats. Besides, the reduction in adhesion molecules expression, in collagen (extracellular matrix), and the generation of inflammatory mediators caused a reduction in leukocyte migration, in these rats. In this model, we also observed reduction in lung allergic inflammation induced by ovalbumin. However, in this situation, this response was age-dependent. Considering the epigenetic mechanisms are crucial for chromatin structure reprogramming and gene expression during development and cell differentiation, we hypothesized that molecular mechanisms, including epigenetic alterations due to global undernutrition throughout the gestational period might be involved in the mechanisms of the attenuation of inflammatory response, acute and lung allergic, observed in Wistar rats. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ECHEM, CINTHYA; DA COSTA, TIAGO JANUARIO; OLIVEIRA, VANESSA; COLLI, LUCAS GIGLIO; LANDGRAF, MARISTELLA ALMEIDA; RODRIGUES, STEPHEN FERNANDES; PINHO FRANCO, MARIA DO CARMO; LANDGRAF, RICHARDT GAMA; SANTOS-EICHLER, ROSANGELA APARECIDA; BOMFIM, GISELE FACHOLI; et al. Mitochondrial DNA: A new driver for sex differences in spontaneous hypertension. PHARMACOLOGICAL RESEARCH, v. 144, p. 142-150, JUN 2019. (15/04281-0, 12/51104-8, 17/02042-3)

MIYAMOTO, JACKSON G.; ANDRADE, FABIO B.; FERRAZ, CAMILA R.; CANDIDO, DENISE M.; KNYSAK, IRENE; VENANCIO, EMERSON J.; VERRI, JR., WALDICEU A.; LANDGRAF, MARISTELLA A.; LANDGRAF, RICHARDT G.; KWASNIEWSKI, FABIO H.. A comparative study of pathophysiological alterations in scorpionism induced by Tityus serrulatus and Tityus bahiensis venoms. Toxicon, v. 141, p. 25-33, JAN 2018. (12/51104-8, 17/02042-3)

BALBINO, ALEKSANDRO M.; SILVA, MARINA M.; AZEVEDO, GABRIELA A.; GIL, NOEMI L.; FERREIRA, RENAIDE R.; DOS SANTOS, LEILA A.; GASPARIN, REBECA M.; FERNANDES, LILIAM; LANDGRAF, MARISTELLA A.; LANDGRAF, RICHARDT G.. Intrauterine Malnutrition Reduced Long Leptin Receptor Isoform Expression and Proinflammatory Cytokine Production in Male Rat Pulmonary Endothelial Cells Stimulated by Lipopolysaccharide. Mediators of Inflammation, 2018. (14/18760-4, 10/01404-0, 12/51104-8, 17/02042-3)

LANDGRAF, MARISTELLA A.; SILVA, REINALDO C.; CORREA-COSTA, MATHEUS; HIYANE, MEIRE I.; CARVALHO, MARIA HELENA C.; LANDGRAF, RICHARDT G.; CAMARA, NIELS O. S.. Leptin Downregulates LPS-Induced Lung Injury: Role of Corticosterone and Insulin. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 33, n. 3, p. 835-846, 2014. (12/10512-6, 12/51104-8, 12/02270-2, 10/01404-0)

SILVA, REINALDO C.; LANDGRAF, MARISTELLA A.; CORREA-COSTA, MATHEUS; SEMEDO, PATRICIA; CENEDEZE, MARCOS A.; PACHECO-SILVA, ALVARO; LANDGRAF, RICHARDT G.; CAMARA, NIELS O. S.. Acute Kidney Injury Reduces Phagocytic and Microbicidal Capacities of Alveolar Macrophages. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v. 31, n. 2-3, p. 179-188, 2013. (07/07139-3, 12/51104-8, 10/01404-0)