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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of 6% Tetrastarch and Lactated Ringer's Solution on Extravascular Lung Water and Markers of Acute Renal Injury in Hemorrhaged, Isoflurane-Anesthetized Healthy Dogs

Texto completo
Autor(es):
Diniz, M. S. [1] ; Teixeira-Neto, F. J. [2] ; Celeita-Rodriguez, N. [1] ; Girotto, C. H. [1] ; Fonseca, M. W. [1] ; Oliveira-Garcia, A. C. [2] ; Lopez-Castaneda, B. [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Fac Med, Botucatu, SP - Brazil
[2] Univ Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF VETERINARY INTERNAL MEDICINE; v. 32, n. 2, p. 712-721, MAR-APR 2018.
Citações Web of Science: 3
Resumo

BackgroundTetrastarch can cause acute kidney injury (AKI) in humans with sepsis, but less likely to result in tissue edema than lactated Ringer's solution (LRS). ObjectivesCompare effects of volume replacement (VR) with LRS and 6% tetrastarch solution (TS) on extravascular lung water (EVLW) and markers of AKI in hemorrhaged dogs. AnimalsSix healthy English Pointer dogs (19.7-35.3 kg). MethodsProspective crossover study. Animals underwent anesthesia without hemorrhage (Control). Two weeks later, dogs hemorrhaged under anesthesia on 2 occasions (8-week washout intervals) and randomly received VR with LRS or TS at 3 : 1 or 1 : 1 of shed blood, respectively. Anesthesia was maintained until 4 hour after VR for EVLW measurements derived from transpulmonary thermodilution cardiac output. Neutrophil gelatinase-associated lipocalin (NGAL) and creatinine concentrations in plasma and urine were measured until 72 hour after VR. ResultsThe EVLW index (mL/kg) was lower at 1 hour after TS (10.0 1.9) in comparison with controls (11.9 +/- 3.4, P = 0.04), and at 4 hour after TS (9.7 +/- 1.9) in comparison with LRS (11.8 +/- 2.7, P = 0.03). Arterial oxygen partial pressure-to-inspired oxygen fraction ratio did not differ among treatments from 0.5 to 4 hour after VR. Urine NGAL/creatinine ratio did not differ among treatments and remained below threshold for AKI (120,000 pg/mg). Conclusions and Clinical ImportanceAlthough TS causes less EVLW accumulation than LRS, neither fluid produced evidence of lung edema (impaired oxygenation). Both fluids appear not to cause AKI when used for VR after hemorrhage in healthy nonseptic dogs. (AU)

Processo FAPESP: 17/19711-5 - Effects of 6% Tetrastarch and lactated Ringer's solution on extravascular lung water and markers of acute renal injury in hemorrhaged, isoflurane-anesthetized healthy dogs
Beneficiário:Francisco José Teixeira Neto
Linha de fomento: Auxílio à Pesquisa - Publicações científicas - Artigo
Processo FAPESP: 14/25115-8 - Uma abordagem dos paradigmas da fluidoterapia no período perioperatório em pequenos animais
Beneficiário:Francisco José Teixeira Neto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/04810-2 - Avaliação do hidroxietilamido de terceira geração (Tetrastarch) em relação ao Ringer Lactato como fluido de reposição em animais sadios submetidos à hemodiluição normovolêmica aguda
Beneficiário:Miriely Steim Diniz
Linha de fomento: Bolsas no Brasil - Doutorado