Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal

Autor(es)

Batista-Duharte, Alexander ^[1] ; Tellez-Martinez, Damiana ^[1] ; Portuondo Fuentes, Deivys Leandro ^[1] ; Carlos, Iracilda Zeppone ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Rodovia Araraquara Jau Km 1, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PHARMACOLOGICAL RESEARCH; v. 129, p. 237-250, MAR 2018.
• Citações Web of Science: 7

Resumo

Adjuvants are substances used to enhance the efficacy of vaccines. They influence the magnitude and alter the quality of the adaptive immune response to vaccine antigens by amplifying or modulating different signals involved in the innate immune response. The majority of known adjuvants have been empirically identified. The limited immunogenicity of new vaccine antigens and the need for safer vaccines have increased the importance of identifying single, well-defined adjuvants with known cellular and molecular mechanisms for rational vaccine design. Depletion or functional inhibition of CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) by molecular adjuvants has become an emergent approach in this field. Different successful results have been obtained for specific vaccines, but there are still unresolved issues such as the risk of autoimmune disease induction, the involvement of cells other than Tregs and optimization for different conditions. This work provides a comprehensive analysis of current approaches to inhibit Tregs with molecular adjuvants for vaccine improvement, highlights the progress being made, and describes ongoing challenges. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 16/04250-0 - Papel das células t reguladoras CD4+CD25+FOXP3+ na resposta imune contra Sporothrix schenckii após infecção e vacinação
• Beneficiário: Alexander Batista Duharte
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado