Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

New Insights on Temporal Lobe Epilepsy Based on Plasticity-Related Network Changes and High-Order Statistics

Texto completo
Autor(es):
Kinjo, Erika Reime [1] ; Royero Rodriguez, Pedro Xavier [1] ; dos Santos, Bianca Araujo [1] ; Vilar Higa, Guilherme Shigueto [2, 1, 3] ; Ayres Ferraz, Mariana Sacrini [1] ; Schmeltzer, Christian [4, 1] ; Rudiger, Sten [4] ; Kihara, Alexandre Hiroaki [2, 1, 3]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Lab Neurogenet, Sao Bernardo Do Campo, SP - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Fisiol & Biofis, Sao Paulo, SP - Brazil
[4] Humboldt Univ, Inst Phys, Berlin - Germany
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Molecular Neurobiology; v. 55, n. 5, p. 3990-3998, MAY 2018.
Citações Web of Science: 1
Resumo

Epilepsy is a disorder of the brain characterized by the predisposition to generate recurrent unprovoked seizures, which involves reshaping of neuronal circuitries based on intense neuronal activity. In this review, we first detailed the regulation of plasticity-associated genes, such as ARC, GAP-43, PSD-95, synapsin, and synaptophysin. Indeed, reshaping of neuronal connectivity after the primary, acute epileptogenesis event increases the excitability of the temporal lobe. Herein, we also discussed the heterogeneity of neuronal populations regarding the number of synaptic connections, which in the theoretical field is commonly referred as degree. Employing integrate-and-fire neuronal model, we determined that in addition to increased synaptic strength, degree correlations might play essential and unsuspected roles in the control of network activity. Indeed, assortativity, which can be described as a condition where high-degree correlations are observed, increases the excitability of neural networks. In this review, we summarized recent topics in the field, and data were discussed according to newly developed or unusual tools, as provided by mathematical graph analysis and high-order statistics. With this, we were able to present new foundations for the pathological activity observed in temporal lobe epilepsy. (AU)

Processo FAPESP: 11/50151-0 - Fenômenos dinâmicos em redes complexas: fundamentos e aplicações
Beneficiário:Elbert Einstein Nehrer Macau
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/16711-6 - Relação entre acoplamento celular e microRNAs no desenvolvimento, adaptação e degeneração do sistema nervoso
Beneficiário:Alexandre Hiroaki Kihara
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/50122-0 - Fenômenos dinâmicos em redes complexas: fundamentos e aplicações
Beneficiário:Elbert Einstein Nehrer Macau
Linha de fomento: Auxílio à Pesquisa - Temático