New Insights on Temporal Lobe Epilepsy Based on Plasticity-Related Network Changes and High-Order Statistics

Author(s)

Kinjo, Erika Reime ^[1] ; Royero Rodriguez, Pedro Xavier ^[1] ; dos Santos, Bianca Araujo ^[1] ; Vilar Higa, Guilherme Shigueto ^{[2, 1, 3]} ; Ayres Ferraz, Mariana Sacrini ^[1] ; Schmeltzer, Christian ^{[4, 1]} ; Rudiger, Sten ^[4] ; Kihara, Alexandre Hiroaki ^{[2, 1, 3]}

Affiliation

^[1] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Lab Neurogenet, Sao Bernardo Do Campo, SP - Brazil

^[2] Univ Sao Paulo, Inst Ciencias Biomed, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Dept Fisiol & Biofis, Sao Paulo, SP - Brazil

^[4] Humboldt Univ, Inst Phys, Berlin - Germany

• Document type: Journal article
• Source: Molecular Neurobiology; v. 55, n. 5, p. 3990-3998, MAY 2018.
• Web of Science Citations: 1

Abstract

Epilepsy is a disorder of the brain characterized by the predisposition to generate recurrent unprovoked seizures, which involves reshaping of neuronal circuitries based on intense neuronal activity. In this review, we first detailed the regulation of plasticity-associated genes, such as ARC, GAP-43, PSD-95, synapsin, and synaptophysin. Indeed, reshaping of neuronal connectivity after the primary, acute epileptogenesis event increases the excitability of the temporal lobe. Herein, we also discussed the heterogeneity of neuronal populations regarding the number of synaptic connections, which in the theoretical field is commonly referred as degree. Employing integrate-and-fire neuronal model, we determined that in addition to increased synaptic strength, degree correlations might play essential and unsuspected roles in the control of network activity. Indeed, assortativity, which can be described as a condition where high-degree correlations are observed, increases the excitability of neural networks. In this review, we summarized recent topics in the field, and data were discussed according to newly developed or unusual tools, as provided by mathematical graph analysis and high-order statistics. With this, we were able to present new foundations for the pathological activity observed in temporal lobe epilepsy. (AU)

• FAPESP's process: 11/50151-0 - Dynamical phenomena in complex networks: fundamentals and applications
• Grantee: Elbert Einstein Nehrer Macau
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
• Grantee: Elbert Einstein Nehrer Macau
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/16711-6 - MicroRNAs and cell coupling interplay in the development, adaptation and degeneration of the nervous system
• Grantee: Alexandre Hiroaki Kihara
• Support Opportunities: Regular Research Grants