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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Insights on Temporal Lobe Epilepsy Based on Plasticity-Related Network Changes and High-Order Statistics

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Kinjo, Erika Reime [1] ; Royero Rodriguez, Pedro Xavier [1] ; dos Santos, Bianca Araujo [1] ; Vilar Higa, Guilherme Shigueto [2, 1, 3] ; Ayres Ferraz, Mariana Sacrini [1] ; Schmeltzer, Christian [4, 1] ; Rudiger, Sten [4] ; Kihara, Alexandre Hiroaki [2, 1, 3]
Total Authors: 8
[1] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Lab Neurogenet, Sao Bernardo Do Campo, SP - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Fisiol & Biofis, Sao Paulo, SP - Brazil
[4] Humboldt Univ, Inst Phys, Berlin - Germany
Total Affiliations: 4
Document type: Journal article
Source: Molecular Neurobiology; v. 55, n. 5, p. 3990-3998, MAY 2018.
Web of Science Citations: 1

Epilepsy is a disorder of the brain characterized by the predisposition to generate recurrent unprovoked seizures, which involves reshaping of neuronal circuitries based on intense neuronal activity. In this review, we first detailed the regulation of plasticity-associated genes, such as ARC, GAP-43, PSD-95, synapsin, and synaptophysin. Indeed, reshaping of neuronal connectivity after the primary, acute epileptogenesis event increases the excitability of the temporal lobe. Herein, we also discussed the heterogeneity of neuronal populations regarding the number of synaptic connections, which in the theoretical field is commonly referred as degree. Employing integrate-and-fire neuronal model, we determined that in addition to increased synaptic strength, degree correlations might play essential and unsuspected roles in the control of network activity. Indeed, assortativity, which can be described as a condition where high-degree correlations are observed, increases the excitability of neural networks. In this review, we summarized recent topics in the field, and data were discussed according to newly developed or unusual tools, as provided by mathematical graph analysis and high-order statistics. With this, we were able to present new foundations for the pathological activity observed in temporal lobe epilepsy. (AU)

FAPESP's process: 11/50151-0 - Dynamical phenomena in complex networks: fundamentals and applications
Grantee:Elbert Einstein Nehrer Macau
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/16711-6 - MicroRNAs and cell coupling interplay in the development, adaptation and degeneration of the nervous system
Grantee:Alexandre Hiroaki Kihara
Support type: Regular Research Grants
FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
Grantee:Elbert Einstein Nehrer Macau
Support type: Research Projects - Thematic Grants