| Texto completo | |
| Autor(es): |
Souza, Matheus S.
[1]
;
da Silva, Cecilia C. P.
[1]
;
Almeida, Leonardo R.
[1]
;
Diniz, Luan F.
[1]
;
Andrade, Marcelo B.
[1]
;
Ellena, Javier
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Inst Fis Sao Carlos, CP 369, BR-13560970 Sao Carlos, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Molecular Structure; v. 1161, p. 412-423, JUN 5 2018. |
| Citações Web of Science: | 1 |
| Resumo | |
5-Fluorocytosine (5-FC) has been widely used for the treatment of fungal infections and recently was found to exert an extraordinary antineoplastic activity in gene directed prodrug therapy. However, despite of its intense use, 5-FC exhibits tabletability issues due its physical instability in humid environments, leading to transition from the anhydrous to monohydrate phase. By considering that salt formation is an interesting strategy to overcome this problem, in this paper crystal engineering approach was applied to the supramolecular synthesis of new 5-FC salts with sulfuric, hydrobromic and methanesulfonic inorganic acids. A total of four structures were obtained, namely 5-FC sulfate monohydrate (1:1:1), 5-FC hydrogen sulfate (1:1), 5-FC mesylate (1:1) and 5-FC hydrobromide (1:1), the last one being a polymorphic form of a structure already reported in the literature. These novel salts were structurally characterized by single crystal X-ray diffraction and its supramolecular organization were analyses by Hirshfeld surface analysis. The vibrational behavior was evaluated by Raman spectroscopy and it was found to be consistent with the crystal structures. (C) 2018 Elsevier B.V. All rights reserved. (AU) | |
| Processo FAPESP: | 13/03487-8 - Centro de caracterização de novas espécies minerais: espectroscopia Raman, difração por raios X e nêutrons, e microssonda eletrônica |
| Beneficiário: | Marcelo Barbosa de Andrade |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 16/09152-6 - Estudo estrutural e funcional de hidrolases de glicosídeos celulossomais termofílicas envolvidas no processo de hidrólise de biomassa lignocelulósica |
| Beneficiário: | Leonardo Rodrigues de Almeida |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 15/25694-0 - Obtenção, caracterização e avaliação de novas formas sólidas cristalinas de fármacos usados no tratamento da tuberculose |
| Beneficiário: | Luan Farinelli Diniz |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |