| Full text | |
| Author(s): |
Souza, Matheus S.
[1]
;
da Silva, Cecilia C. P.
[1]
;
Almeida, Leonardo R.
[1]
;
Diniz, Luan F.
[1]
;
Andrade, Marcelo B.
[1]
;
Ellena, Javier
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Inst Fis Sao Carlos, CP 369, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Journal of Molecular Structure; v. 1161, p. 412-423, JUN 5 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
5-Fluorocytosine (5-FC) has been widely used for the treatment of fungal infections and recently was found to exert an extraordinary antineoplastic activity in gene directed prodrug therapy. However, despite of its intense use, 5-FC exhibits tabletability issues due its physical instability in humid environments, leading to transition from the anhydrous to monohydrate phase. By considering that salt formation is an interesting strategy to overcome this problem, in this paper crystal engineering approach was applied to the supramolecular synthesis of new 5-FC salts with sulfuric, hydrobromic and methanesulfonic inorganic acids. A total of four structures were obtained, namely 5-FC sulfate monohydrate (1:1:1), 5-FC hydrogen sulfate (1:1), 5-FC mesylate (1:1) and 5-FC hydrobromide (1:1), the last one being a polymorphic form of a structure already reported in the literature. These novel salts were structurally characterized by single crystal X-ray diffraction and its supramolecular organization were analyses by Hirshfeld surface analysis. The vibrational behavior was evaluated by Raman spectroscopy and it was found to be consistent with the crystal structures. (C) 2018 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 13/03487-8 - Center of characterization of new mineral species: Raman spectroscopy, electron microprobe and X-ray and neutron diffraction |
| Grantee: | Marcelo Barbosa de Andrade |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/09152-6 - Structural and functional studies of cellulosomal thermophilic glycoside hydrolases involved on lignocellulosic biomass hydrolysis |
| Grantee: | Leonardo Rodrigues de Almeida |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/25694-0 - Obtaining, characterization and evaluation of novel crystalline solid forms of drugs used treatment of tuberculosis |
| Grantee: | Luan Farinelli Diniz |
| Support Opportunities: | Scholarships in Brazil - Master |