An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation

Autor(es)

Fonseca-Santos, Bruno ^[1] ; Chorilli, Marlus ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 86, p. 129-143, MAY 1 2018.
• Citações Web of Science: 15

Resumo

Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the oral cavity that takes way the formulation from the buccal site and decreases the bioavailability of drugs. The use of mucoadhesive polymers in buccal drug delivery shows assessing buccal drug permeation and absorption, however some studies bring an in vivo performance. This review points to the use of polymers in the manufacture of drug delivery systems (hydrogels, films and tablets) and shows the results of their in vivo performance tests. (AU)

• Processo FAPESP: 15/05394-2 - Avaliação do potencial de sistemas nanoestruturados baseados em tensoativos para administração nasal de trans-resveratrol na otimização da terapia da Doença de Alzheimer
• Beneficiário: Bruno da Fonseca dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 13/03746-3 - Sistemas precursores de cristais líquidos mucoadesivos para administração bucal de curcumina no tratamento do câncer bucal
• Beneficiário: Bruno da Fonseca dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado