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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation

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Author(s):
Fonseca-Santos, Bruno [1] ; Chorilli, Marlus [1]
Total Authors: 2
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 86, p. 129-143, MAY 1 2018.
Web of Science Citations: 15
Abstract

Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. The main difficulty for administration via the buccal route is an effective physiological removal mechanism of the oral cavity that takes way the formulation from the buccal site and decreases the bioavailability of drugs. The use of mucoadhesive polymers in buccal drug delivery shows assessing buccal drug permeation and absorption, however some studies bring an in vivo performance. This review points to the use of polymers in the manufacture of drug delivery systems (hydrogels, films and tablets) and shows the results of their in vivo performance tests. (AU)

FAPESP's process: 13/03746-3 - Mucoadhesive precursor systems of liquid crystals for buccal administration of curcumin in the treatment of oral cancer
Grantee:Bruno da Fonseca dos Santos
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/05394-2 - Evaluating the potential of nanostructured surfactant-based systems to intranasal administration of trans-resveratrol in the optimization of Alzheimer's disease therapy
Grantee:Bruno da Fonseca dos Santos
Support type: Scholarships in Brazil - Doctorate