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Mucoadhesive precursor systems of liquid crystals for buccal administration of curcumin in the treatment of oral cancer

Grant number: 13/03746-3
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Marlus Chorilli
Grantee:Bruno da Fonseca dos Santos
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Oral cancer is a highly incident disease in world population and it can cause facial deformities and death. The choice treatment is costly and usually involves the administration of chemotherapy, which may have cytotoxic action also on healthy cells, which affect significantly the quality and survival of patients. Thus, many researchers are working in discovering new molecules, which comes from natural sources that may have therapeutic interest. Curcumin, naturally occurring compound isolated from the rhizomes of Curcuma longa, it has shown activity in the treatment of oral cancer, it acts on the nuclear factor kappa beta (NF-kB), which mediates expression of genes that are involved in promoting tumors, angiogenesis and metastasis. However, its clinical use is facing many challenges, mainly due to their physicochemical characteristics and low oral bioavailability. Next, when incorporated in nanostructured systems precursors liquid crystal (SPLC) added of mucoadhesive polymer adjuvant, shows to be an interesting option to enable its use in the treatment of oral cancer, since these systems can protect the drug from degradation and to increase the residence time of the formulation in the oral environment, allowing a controlled release on an specific site of action. Furthermore, buccal administration of SPLC containing this drug can be advantageous, since the buccal mucosa has high permeability and high blood flow, allowing the local or systemic treatment and avoiding first pass metabolism, optimizing the local action. This project aims to develop a SPLC consisting of polyoxypropylene (5) polyoxyethylene (20) cetyl ether, oleic acid and polymer dispersion aqueous containing poloxamer associated with chitosan for buccal administration of curcumin and, subsequently, investigate the in vitro activity of formulations. Thus, we aim to develop a delivery system in nanostructural level for use in the treatment of oral cancer.

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONSECA-SANTOS, BRUNO; BONIFACIO, BRUNA VIDAL; BAUB, TAIS MARIA; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. In-Situ Gelling Liquid Crystal Mucoadhesive Vehicle for Curcumin Buccal Administration and Its Potential Application in the Treatment of Oral Candidiasis. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 15, n. 6, p. 1334-1344, JUN 2019. Web of Science Citations: 0.
FONSECA-SANTOS, BRUNO; CHORILLI, MARLUS. An overview of polymeric dosage forms in buccal drug delivery: State of art, design of formulations and their in vivo performance evaluation. Materials Science & Engineering C-Materials for Biological Applications, v. 86, p. 129-143, MAY 1 2018. Web of Science Citations: 15.
FONSECA-SANTOS, BRUNO; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARIUS. A simple reversed phase high-performance liquid chromatography (HPLC) method for determination of in situ gelling curcumin-loaded liquid crystals in in vitro performance tests. ARABIAN JOURNAL OF CHEMISTRY, v. 10, n. 7, p. 1029-1037, NOV 2017. Web of Science Citations: 5.
FONSECA-SANTOS, BRUNO; DOS SANTOS, ALINE MARTINS; RODERO, CAMILA FERNANDA; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 11, p. 4553-4562, 2016. Web of Science Citations: 10.

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Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DE SISTEMAS PRECURSORES DE CRISTAIS LÍQUIDOS (SPCL) MUCOADESIVOS, SPCL MUCOADESIVOS OBTIDOS E SEUS USOS BR1020160033527 - Universidade Estadual Paulista (UNESP) . Marlus Chorilli; Bruno Da Fonseca Dos Santos; Giovana Maria Fioramonti Calixto; Jéssica Bernegossi; Maria Palmira Daflon Gremião - February 2016, 17