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Mucoadhesive precursor systems of liquids crystals for buccal admnistration of antigelatinolytic peptide associated with photodynamic therapy in the treatment of oral cancer

Grant number: 13/01565-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2013
Effective date (End): January 31, 2017
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Marlus Chorilli
Grantee:Giovana Maria Fioramonti Calixto Balian
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):16/06337-5 - Evaluation of the effects of CTT1-loaded liquid crystalline system associated to photodynamic therapy in tumor growth using chorioallantoic membrane, BE.EP.DR


Oral cancer, which affects the tongue and oral cavity, is a highly infectious disease incident in world population and can cause disability, facial deformities and death. The choice treatment is costly and usually involves the administration of chemotherapy, which may have cytotoxic action also on healthy cells, and numerous adverse reactions, such as fall and hair loss, sore in mouth, nausea, vomiting and pain which affect significantly the quality and survival of patients. Therefore, it becomes necessary to search for more functional, innovative and clinically viable treatments. In this context, the use of bioactive molecules, as peptide CTT1, proves to be an innovative alternative and effective because the CTT1 showed specificity for squamous cell carcinoma of the tongue, the most common form of oral cancer. However, the clinical use of peptides faces many challenges, mainly due to their physicochemical characteristics and low oral bioavailability, which involve the administration by the parenteral route. Using this route of administration can result in poor patient compliance to treatment due to the necessity of repeated injections, once the CTT1 have reduced half-life. Therefore, it becomes necessary to develop drug delivery systems clinically safe and appropriate to enable the use of peptides. The buccal administration of nanostructured liquid crystal precursors systems (CLPS) with mucoadhesive cationic polymer adjuvants emerges as a valuable strategy for administration CTT1, whereas the buccal mucosa has high permeability and high blood flow, which may enhance absorption of CTT1. Furthermore, the SPCL may enable the incorporation of CTT1 concomitant with the methylene blue (MB) photosensitizer allowing association of PDT with the peptide antitumor therapy, which may enhance the treatment of oral cancer. This project aims to develop a SPCL consisting of cetyl alcohol ethoxylated propoxylated 20 and 5, oleic acid and aqueous phase containing chitosan polymer dispersion with or without polyethyleneimine dispersion for buccal delivery of CTT1 peptide and AM and later investigate the in vitro and in vivo cytotoxic and photocytotoxic action of the formulations. Thus, we intend to develop a delivery system for nanostructural level for use in the treatment of oral cancer. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FIORAMONTI CALIXTO, GIOVANA MARIA; VICTORELLI, FRANCESCA DAMIANI; DOVIGO, LIVIA NORDI; CHORILLI, MARLUS. Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery. AAPS PHARMSCITECH, v. 19, n. 2, p. 820-836, FEB 2018. Web of Science Citations: 2.
VICTORELLI, FRANCESCA DAMIANI; FIORAMONTI CALIXTO, GIOVANA MARIA; DOS SANTOS RAMOS, MATHEUS APARECIDO; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Metronidazole-Loaded Polyethyleneimine and Chitosan-Based Liquid Crystalline System for Treatment of Staphylococcal Skin Infections. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 14, n. 1, p. 227-237, JAN 2018. Web of Science Citations: 4.
AIDA, KELLY LIMI; KRELING, PAULA FERNANDA; CAIAFFA, KARINA SAMPAIO; FIORAMONTI CALIXTO, GIOVANA MARIA; CHORILLI, MARLUS; SPOLIDORIO, DENISE M. P.; SANTOS-FILHO, NORIVAL ALVES; CILLI, EDUARDO MAFFUD; DUQUE, CRISTIANE. Antimicrobial peptide-loaded liquid crystalline precursor bioadhesive system for the prevention of dental caries. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 13, p. 3081-3091, 2018. Web of Science Citations: 5.
FIORAMONTI CALIXTO, GIOVANA MARIA; DUQUE, CRISTIANE; AIDA, KELLY LIMI; DOS SANTOS, VANESSA RODRIGUES; MASSUNARI, LOIANE; CHORILLI, MARLUS. Development and characterization of p1025-loaded bioadhesive liquid-crystalline system for the prevention of Streptococcus mutans biofilms. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 13, p. 31-41, 2018. Web of Science Citations: 3.
MONTEIRO E SILVA, SILAS ARANDAS; FIORAMONTI CALIXTO, GIOVANA MARIA; CAJADO, JULIANA; ANTUNES DE CARVALHO, PATRICIA CABALLIERI; RODERO, CAMILA FERNANDA; CHORILLI, MARLUS; LEONARDI, GISLAINE RICCI. Gallic Acid-Loaded Gel Formulation Combats Skin Oxidative Stress: Development, Characterization and Ex Vivo Biological Assays. POLYMERS, v. 9, n. 9 SEP 2017. Web of Science Citations: 0.
FIORAMONTI CALIXTO, GIOVANA MARIA; BERNEGOSSI, JESSICA; DE FREITAS, LAURA MARISE; FONTANA, CARLA RAQUEL; CHORILLI, MARLUS. Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review. Molecules, v. 21, n. 3 MAR 2016. Web of Science Citations: 70.
FIORAMONTI CALIXTO, GIOVANA MARIA; GARCIA, MATHEUS HENRIQUE; CILLI, EDUARDO MAFFUD; CHIAVACCI, LEILA APARECIDA; CHORILLI, MARLUS. Design and Characterization of a Novel p1025 Peptide-Loaded Liquid Crystalline System for the Treatment of Dental Caries. Molecules, v. 21, n. 2 FEB 2016. Web of Science Citations: 12.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BALIAN, Giovana Maria Fioramonti Calixto. Sistemas precursores de cristais líquidos mucoadesivos para administração bucal de peptídeo antigelatinolítico associados à terapia fotodinâmica no tratamento do câncer bucal. 2017. 137 f. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas..

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