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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Omega-3 Fatty Acids Reduce Inflammation in Rat Apical Periodontitis

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Autor(es):
Azuma, Mariane Maffei [1, 2] ; Eduardo Gomes-Filho, Joao [1] ; Ervolino, Edilson [3] ; Moraes Cardoso, Carolina de Barros [1] ; Pipa, Camila Barbosa [1] ; Kawai, Toshihisa [4] ; Conti, Leticia Citelli [1] ; Angelo Cintra, Luciano Tavares [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Dept Endodont, Aracatuba Dent Sch, Aracatuba, SP - Brazil
[2] Univ Michigan, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 - USA
[3] Univ Estadual Paulista UNESP, Dept Basic Sci, Aracatuba Dent Sch, Aracatuba, SP - Brazil
[4] Nova Southeastern Univ, Dept Periodontol, Coll Dent Med, Ft Lauderdale, FL 33314 - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF ENDODONTICS; v. 44, n. 4, p. 604-608, APR 2018.
Citações Web of Science: 5
Resumo

Introduction: The effects of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) on pro-and anti-inflammatory mediators were evaluated in a rat model of pulp exposure induced apical periodontitis (AP). Methods: Twenty-eight male Wistar rats were divided into 4 groups: control, untreated rats (group C); control rats treated with omega-3 PUFAs (group C-O); rats with pulp exposure induced AP (group AP); and rats with pulp exposure induced AP treated with w-3 PUFAs (group AP-O). Omega-3 PUFAs were administered orally once a day for 15 days before pulp exposure; this treatment was continued for 30 days after pulp exposure. The rats were sacrificed 30 days after pulp exposure, and their dissected jaws were subjected to immunohistochemical analysis to detect immunoreactivity for tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-1 beta, and IL-10 on the periapical bone surface. The results were statistically evaluated using analysis of variance and the Tukey post-test. The significance level was set at 5%. Results: Immunoreactivity for the proinflammatory cytokines TNF-alpha, IL-6, IL-1 beta, and IL-17 was higher in the AP group than in the AP-O, C, and C-O groups (P < .05). Immunoreactivity for the anti-inflammatory cytokine IL-10 was lower in the AP group than in the AP-O group (P < .05). Conclusions: Supplementation with omega-3 PUFAs can modulate the inflammatory response in rat AP, decreasing levels of INF-alpha, IL-6, IL-1 beta, and IL-17 but increasing levels of IL-10. (AU)

Processo FAPESP: 13/26390-0 - Influência local e sistêmica da suplementação alimentar com o ácido graxo ômega-3 em ratos com infecção endodôntica
Beneficiário:Mariane Maffei Azuma
Linha de fomento: Bolsas no Brasil - Doutorado