Treg and NK cells related cytokines are associated with deep rectosigmoid endometriosis and clinical symptoms related to the disease

Autor(es)

Gueuvoghlanian-Silva, Barbara Yasmin ^[1] ; Bellelis, Patrick ^[2] ; Barbeiro, Denise Frediani ^[3] ; Hernandes, Camila ^[1] ; Podgaec, Sergio ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Hosp Israelita Albert Einstein, Ave Albert Einstein 627, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Med Sch, Dept Obstet & Gynecol, Av Dr Eneas de Carvalho Aguiar 255, BR-05403000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Med Sch, Med Invest Lab 51, Av Dr Arnaldo 455, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF REPRODUCTIVE IMMUNOLOGY; v. 126, p. 32-38, APR 2018.
• Citações Web of Science: 9

Resumo

The aim of this study was to evaluate Treg and NK cells related cytokines in deep infiltrating endometriosis lesions and its relationship with clinical symptoms of the disease. mRNA expression of Transforming Growth Factor Beta (TGFB), Interleukin (IL)10, Interferon Gamma (IFNG), IL7, and IL15 was analyzed by Real-Time PCR in eutopic endometrium and rectosigmoid lesions from 11 women with deep infiltrating endometriosis and in eutopic endometrium from 11 healthy women. IL10, IFNG, and IL7 expression was significantly higher in endometriotic bowel lesions than in eutopic endometrium from women with endometriosis. IL10 and TGFB expression was significantly higher in endometriotic bowel lesions than in eutopic endometrium from healthy women. In addition, TGFB and IL15 levels correlated positively with deep dyspareunia and cyclic dyschezia, respectively, while IL7 levels correlated negatively with dysmenorrhea. Deep infiltrating rectosigmoid endometriosis displays alterations in Treg and NK cells related cytokine, and TGFB, IL7 and IL15 expression is related with dyspareunia, dysmenorrhea and cyclic dyschezia, respectively, in patients with the disease. (AU)

• Processo FAPESP: 10/00475-0 - A expressão de quimiocinas regulatórias das células natural killer e T-reguladoras em pacientes com endometriose
• Beneficiário: Sérgio Podgaec
• Modalidade de apoio: Auxílio à Pesquisa - Regular