4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation

Autor(es)

Witaicenis, Aline ^[1] ; Souza de Oliveira, Ellen Cristina ^[1] ; Tanimoto, Alexandre ^[1] ; Goncalves Zorzella-Pezavento, Sofia Fernanda ^[2] ; de Oliveira, Silvio Luis ^[2] ; Sartori, Alexandrina ^[2] ; Di Stasi, Luiz Claudio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Inst Biosci, Dept Pharmacol, Campus Botucatu, Sao Paulo, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Inst Biosci, Dept Microbiol & Immunol, Campus Botucatu, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Chemico-Biological Interactions; v. 280, p. 59-63, JAN 25 2018.
• Citações Web of Science: 2

Resumo

4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. Recent studies have shown that 4-methylesculetin has a promising potentiality to treat inflammatory diseases, especially those related to reactive oxygen species, as inflammatory bowel disease. Based on this, the present study aims to investigate the intestinal anti-inflammatory activity of 4-methylesculetin in dextran sulfate sodium (DSS) model. For this purpose, mice received DSS 5% for 5 days followed by 2 days of filtered tap water. Treated groups received orally 5 or 25 mg/kg of 4-methylesculetin daily since the first day. Macroscopic, microscopic and biochemical parameters were evaluated. 4-methylesculetin (25 mg/kg) improved microscopic parameters, decreased MPO activity, reduced the colonic levels of IL-6 and counteracted GSH depletion when compared with DSS-control group. Our results show the intestinal anti-inflammatory activity of 4-methylesculetin in DSS model, which is related to its antioxidant and anti-inflammatory properties. This way, 4-methylesculetin, is a new potential compound for treatment of both types of IBD. (AU)

• Processo FAPESP: 13/01297-7 - Avaliação da atividade anti-inflamatória intestinal de 4-metilesculetina no modelo experimental de colite induzida por DSS em linhagens de camundongos selecionadas geneticamente
• Beneficiário: Ellen Cristina Souza de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 11/50512-2 - Doença inflamatória intestinal (DII): novos marcadores moleculares e atividade anti-inflamatória intestinal de fármacos e produtos de origem vegetal
• Beneficiário: Luiz Claudio Di Stasi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/50824-4 - Avaliacao dos mecanismos de acao antiinflamatoria intestinal de esculetina, 4-metilesculetina e esculina sobre novos marcadores moleculares.
• Beneficiário: Aline Witaicenis Fantinati
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado