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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation

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Author(s):
Witaicenis, Aline [1] ; Souza de Oliveira, Ellen Cristina [1] ; Tanimoto, Alexandre [1] ; Goncalves Zorzella-Pezavento, Sofia Fernanda [2] ; de Oliveira, Silvio Luis [2] ; Sartori, Alexandrina [2] ; Di Stasi, Luiz Claudio [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista, UNESP, Inst Biosci, Dept Pharmacol, Campus Botucatu, Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Inst Biosci, Dept Microbiol & Immunol, Campus Botucatu, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Chemico-Biological Interactions; v. 280, p. 59-63, JAN 25 2018.
Web of Science Citations: 2
Abstract

4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. Recent studies have shown that 4-methylesculetin has a promising potentiality to treat inflammatory diseases, especially those related to reactive oxygen species, as inflammatory bowel disease. Based on this, the present study aims to investigate the intestinal anti-inflammatory activity of 4-methylesculetin in dextran sulfate sodium (DSS) model. For this purpose, mice received DSS 5% for 5 days followed by 2 days of filtered tap water. Treated groups received orally 5 or 25 mg/kg of 4-methylesculetin daily since the first day. Macroscopic, microscopic and biochemical parameters were evaluated. 4-methylesculetin (25 mg/kg) improved microscopic parameters, decreased MPO activity, reduced the colonic levels of IL-6 and counteracted GSH depletion when compared with DSS-control group. Our results show the intestinal anti-inflammatory activity of 4-methylesculetin in DSS model, which is related to its antioxidant and anti-inflammatory properties. This way, 4-methylesculetin, is a new potential compound for treatment of both types of IBD. (AU)

FAPESP's process: 13/01297-7 - Evaluation of intestinal anti-inflammatory activity of 4-methylesculetin in experimental model of DSS-induced colitis in mice genetically selected lines
Grantee:Ellen Cristina Souza de Oliveira
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/50512-2 - Inflammatory bowel disease (IBD): new molecular markers and intestinal anti-inflammatory activity of drugs and plant products
Grantee:Luiz Claudio Di Stasi
Support Opportunities: Regular Research Grants