Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans

Autor(es)

Marcelino, Monica Yonashiro ^[1] ; Borges, Felipe Azevedo ^[2] ; Martins Costa, Ana Flavia ^[3] ; Singulani, Junya de Lacorte ^[1] ; Ribeiro, NathanVinicius ^[3] ; Costa-Orlandi, Caroline Barcelos ^[1] ; Garms, Bruna Cambraia ^[2] ; Mendes-Giannini, Maria Jose Soares ^[1] ; Herculano, Rondinelli Donizetti ^[3] ; Fusco-Almeida, Ana Marisa ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Clin Anal, Rodovia Araraquara Jau, Km 01-S, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, Biochem & Chem Technol, Araraquara, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Bioproc & Biotechnol, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FUTURE MICROBIOLOGY; v. 13, n. 3, p. 359-367, MAR 2018.
• Citações Web of Science: 5

Resumo

Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Materials \& methods: Fluconazole-loaded NRL membrane was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. Conclusion: The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application. (AU)

• Processo FAPESP: 14/17526-8 - Desenvolvimento de um novo sistema empregando o látex natural como liberador de extratos vegetais reforçados por nanopartículas: caracterização física, química e biológica
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/17411-8 - Avaliação da liberação controlada de fármacos utilizando membranas de látex natural como carreador
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Regular