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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans

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Author(s):
Marcelino, Monica Yonashiro [1] ; Borges, Felipe Azevedo [2] ; Martins Costa, Ana Flavia [3] ; Singulani, Junya de Lacorte [1] ; Ribeiro, NathanVinicius [3] ; Costa-Orlandi, Caroline Barcelos [1] ; Garms, Bruna Cambraia [2] ; Mendes-Giannini, Maria Jose Soares [1] ; Herculano, Rondinelli Donizetti [3] ; Fusco-Almeida, Ana Marisa [1]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Clin Anal, Rodovia Araraquara Jau, Km 01-S, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, Biochem & Chem Technol, Araraquara, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Bioproc & Biotechnol, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FUTURE MICROBIOLOGY; v. 13, n. 3, p. 359-367, MAR 2018.
Web of Science Citations: 5
Abstract

Aim: This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans. Materials \& methods: Fluconazole-loaded NRL membrane was obtained by casting method. Results: The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays. Conclusion: The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application. (AU)

FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants