Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Corpus callosum volumes in the 5 years following the first-episode of schizophrenia: Effects of antipsychotics, chronicity and maturation

Texto completo
Autor(es):
de Moura, Mariana T. M. [1] ; Zanetti, Marcus V. [2, 1] ; Duran, Fabio L. S. [2, 1] ; Schaufelberger, Maristela S. [2, 1] ; Menezes, Paulo R. [3] ; Scazufca, Marcia [4] ; Busatto, Geraldo F. [2, 1] ; Serpa, Mauricio H. [2, 1, 5]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Lab Neuroimagem Psiquiatria LIM 21, Dept & Inst Ps, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, NAPNA, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Dept & Inst Psiquiatria, Lab Psicofarmacol Psicopa, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Lab Neurociencias LIM 27, Dept & Inst Psiquiatria, Sao Paulo, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: NEUROIMAGE-CLINICAL; v. 18, p. 932-942, 2018.
Citações Web of Science: 1
Resumo

Background: White matter (WM) structural changes, particularly affecting the corpus callosum (CC), seem to be critically implicated in psychosis. Whether such abnormalities are progressive or static is still a matter of debate in schizophrenia research. Aberrant maturation processes might also influence the longitudinal trajectory of age-related CC changes in schizophrenia patients. We investigated whether patients with first-episode schizophreniarelated psychoses (FESZ) would present longitudinal CC and whole WM volume changes over the 5 years after disease onset. Method: Thirty-two FESZ patients and 34 controls recruited using a population-based design completed a 5-year assessment protocol, including structural MRI scanning at baseline and follow-up. The linear effects of disease duration, clinical outcome and antipsychotic (AP) use over time on WM and CC volumes were studied using both voxelwise and volume-based morphometry analyses. We also examined maturation/aging abnormalities through cross-sectional analyses of age-related trajectories of total WM and CC volume changes. Results: No interaction between diagnosis and time was observed, and clinical outcome did not influence CC volumes in patients. On the other hand, FESZ patients continuously exposed to AP medication showed volume increase over time in posterior CC. Curve-estimation analyses revealed a different aging pattern in FESZ patients versus controls: while patients displayed a linear decline of total WM and anterior CC volumes with age, a non-linear trajectory of total WM and relative preservation of CC volumes were observed in controls. Conclusions: Continuous AP exposure can influence CC morphology during the first years after schizophrenia onset. Schizophrenia is associated with an abnormal pattern of total WM and anterior CC aging during nonelderly adulthood, and this adds complexity to the discussion on the static or progressive nature of structural abnormalities in psychosis. (AU)

Processo FAPESP: 13/03905-4 - Avaliação de diferenças neurobiológicas entre pacientes com transtorno bipolar subtipos i e ii virgens de tratamento
Beneficiário:Marcus Vinicius Zanetti
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/00481-1 - Avaliação longitudinal de 5 anos de alterações morfométricas do corpo caloso em pacientes com primeiro episódio psicótico
Beneficiário:Mariana Tiemi Mine de Moura
Linha de fomento: Bolsas no Brasil - Iniciação Científica