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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Action of the Metalloproteinases in Gonadal Remodeling during Sex Reversal in the Sequential Hermaphroditism of the Teleostei Fish Synbranchus marmoratus (Synbranchiformes: Synbranchidae)

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Autor(es):
Mazzoni, Talita Sarah [1, 2] ; Lo Nostro, Fabiana Laura [3] ; Antoneli, Fernanda Natalia [4] ; Quagio-Grassiotto, Irani [1, 5]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] State Univ Sao Paulo UNESP, Botucatu Biosci Inst, Dept Morphol, Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP - Brazil
[2] Fed Univ Alfenas UNIFAL, Inst Biomed Sci, Dept Cell & Dev Biol, Gabriel Monteiro da Silva 700, BR-37130001 Alfenas, MG - Brazil
[3] Fac Exact & Nat Sci, Dept Biodivers & Expt Biol, Ciudad Univ, Lab 4 & 78, Piso 4To, Pabellon 2, Buenos Aires, DF - Argentina
[4] Univ Estadual Campinas, Inst Biol, Bertrand Russel S-N, BR-13083865 Campinas, SP - Brazil
[5] Aquaculture Ctr UNESP CAUNESP, Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: CELLS; v. 7, n. 5 MAY 2018.
Citações Web of Science: 4
Resumo

Teleostei present great plasticity regarding sex change. During sex reversal, the whole gonad including the germinal epithelium undergoes significant changes, remodeling, and neoformation. However, there is no information on the changes that occur within the interstitial compartment. Considering the lack of information, especially on the role played by metalloproteinases (MMPs) in fish gonadal remodeling, the aim of this study was to evaluate the action of MMPs on gonads of sex reversed females of Synbranchus marmoratus, a fresh water protogynic diandric fish. Gonads were processed for light microscopy and blood samples were used for the determination of plasma sex steroid levels. During sex reversal, degeneration of the ovaries occurred and were gradually replaced by the germinal tissue of the male. The action of the MMPs induces significant changes in the interstitial compartment, allowing the reorganization of germinal epithelium. Leydig cells also showed an important role in female to male reversion. The gonadal transition coincides with changes in circulating sex steroid levels throughout sex reversion. The action of the MMPs, in the gonadal remodeling, especially on the basement membrane, is essential for the establishment of a new functional germinal epithelium. (AU)

Processo FAPESP: 14/00868-3 - Ação das metaloproteinases (MMPs) na remodelação gonadal durante a inversão sexual no hermafroditismo juvenil e sequencial em peixes Teleostei
Beneficiário:Talita Sarah Mazzoni
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/16358-7 - Ação das metaloproteinases (MMPs) e hormônios esteróides na remodelação gonadal durante a inversão sexual no hermafroditismo juvenil e sequencial em peixes Teleostei
Beneficiário:Irani Quagio Grassiotto
Linha de fomento: Auxílio à Pesquisa - Regular