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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Beneficial effects of thyroid hormone on adipose inflammation and insulin sensitivity of obese Wistar rats

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Autor(es):
Panveloski-Costa, Ana C. [1] ; Serrano-Nascimento, Caroline [1] ; Bargi-Souza, Paula [1] ; Poyares, Leonice L. [1] ; Viana, Gabriela de S. [1] ; Nunes, Maria T. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: PHYSIOLOGICAL REPORTS; v. 6, n. 3 FEB 2018.
Citações Web of Science: 4
Resumo

Thyroid hormones play an important role in glucose metabolism and there is evidence of increased prevalence of thyroid dysfunction in obese and diabetic patients. This study aimed at evaluating the thyroid function and the effects of the triiodothyronine (T3) treatment on glycemia control, insulin sensitivity and subclinical inflammation in cafeteria-diet-induced obesity in rats. Obesity was induced in male Wistar rats by offering a cafeteria diet and a subset of the obese rats was treated with T3 (1.5g per 100g of body weight) for a 28-day period. The pituitary-thyroid axis was evaluated by molecular and biochemical parameters. Cytokine content was measured in the serum as well as in the mesenteric and epididymal white adipose tissue. Obese rats exhibited impairment of glycemia control, increased content of inflammatory cytokines in mesenteric white adipose tissue, decreased serum thyrotropin (TSH) concentration and increased sodium/iodide symporter (NIS) and TSH receptor (TSHR) protein content in thyroid gland. T3 treatment improved insulin sensitivity, glucose tolerance, and reduced inflammatory cytokine content in mesenteric white adipose tissue. In the thyroid gland NIS, TSHR, and thyroperoxidase (TPO) content were reduced while thyroglobulin (TG) content was increased by T3. The thyrotrophic response to negative feedback exerted by T3 was preserved in obese rats. The present data reinforce the beneficial effects of T3 treatment of obese rats on the improvement of insulin sensitivity and on the negative modulation of inflammatory cytokine expression in adipose tissue. Moreover, we have evidenced that the pituitary-thyroid axis is affected in obese rats, as illustrated by the impaired TSH secretion. (AU)

Processo FAPESP: 13/05629-4 - Ações genômicas vs não genômicas dos hormônios tiroidianos: mudanças de paradigmas, implicações fisiológicas e perspectivas terapêuticas
Beneficiário:Maria Tereza Nunes
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 11/09014-9 - Efeitos do hormônio tireoidiano na modulação da expressão de citocinas envolvidas na sinalização da insulina na vigência de obesidade ou diabetes
Beneficiário:Ana Carolina Panveloski Costa Salomão
Modalidade de apoio: Bolsas no Brasil - Doutorado