Vaccine effectiveness and use of collar impregnated with insecticide for reducing incidence of Leishmania infection in dogs in an endemic region for visceral leishmaniasis, in Brazil

Autor(es):Mostrar menos -

Lopes, E. G. ^[1] ; Seva, A. P. ^[1] ; Ferreira, F. ^[1] ; Nunes, C. M. ^[2] ; Keid, L. B. ^[3] ; Hiramoto, R. M. ^[4] ; Ferreira, H. L. ^[3] ; Oliveira, T. M. F. S. ^[3] ; Ovallos, F. G. ^[5] ; Galati, E. A. B. ^[5] ; Villegas, T. J. ^[1] ; Bortoletto, D. V. ^[2] ; Valadas, S. Y. O. B. ^[1] ; Soares, R. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, Sao Paulo, SP - Brazil

^[2] Univ Estadual Paulista, Fac Med Vet, Dept Med Vet, Campus Aracatuba, Aracatuba, SP - Brazil

^[3] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Dept Med Vet, Pirassununga, SP - Brazil

^[4] Adolfo Lutz Inst, Ctr Parasitol & Micol, Sao Paulo, SP - Brazil

^[5] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EPIDEMIOLOGY AND INFECTION; v. 146, n. 3, p. 401-406, FEB 2018.
• Citações Web of Science: 5

Resumo

Although a national programme for control of visceral leishmaniosis (VL) is being run in Brazil, the disease continues to spread. This programme is essentially based on culling infected dogs from endemic regions. Thus, there is an urgent need to develop other control measures against VL to deter its advance. Here, a subunit vaccine, a recombinant vaccine, an insecticide-impregnated collar and the associations between these measures were evaluated for reducing the incidence of Leishmania infection in dogs. This was through a cohort study conducted in an endemic region of Brazil, considering the incidence and time of total exposure over a period of 1 year. The incidence of VL was estimated by means of serological and molecular diagnostic tests, 180 and 360 days after the application of the control measures. The estimates of the effectiveness (EF) were not significant in any cohort. The EF of the subunit vaccine, the recombinant vaccine and the collar were 26.4%, 32.8% and 57.7% and the upper limit of the 95% confidence interval for EF were 63.7%, 67.9% and 82.5%, respectively. In conclusion, under the conditions of this study, none of the immunogens for VL control was sufficiently effective to protect dogs against infection. On the other hand, use of collars impregnated with insecticide seems to constitute a method with better prognosis, corroborating other studies in this field. (AU)

• Processo FAPESP: 11/14892-5 - Avaliação da efetividade do emprego de coleira impregnada com inseticida e de vacina recombinante contra leishmaniose visceral canina
• Beneficiário: Estela Gallucci Lopes
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/21796-2 - Avaliação da efetividade do emprego de coleira impregnada com inseticida e de vacina de subunidade contra leishmaniose visceral canina
• Beneficiário: Rodrigo Martins Soares
• Modalidade de apoio: Auxílio à Pesquisa - Regular