Pathological factors and prognosis of resected liver metastases of colorectal carcinoma: implications and proposal for a pathological reporting protocol

Autor(es)

Fonseca, Gilton M. ^[1] ; Herman, Paulo ^[1] ; Faraj, Sheila F. ^[2] ; Kruger, Jaime A. P. ^[1] ; Coelho, Fabricio F. ^[1] ; Jeismann, Vagner B. ^[1] ; Cecconello, Ivan ^[1] ; Alves, Venancio A. F. ^[2] ; Pawlik, Timothy M. ^[3] ; de Mello, Evandro S.

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Digest Surg Div, Dept Gastroenterol, Med Sch, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sao Paulo State Canc Inst, Dept Pathol, Med Sch, Sao Paulo - Brazil

^[3] Ohio State Univ, Dept Surg, Wexner Med Ctr, Columbus, OH 43210 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Histopathology; v. 72, n. 3, p. 377-390, FEB 2018.
• Citações Web of Science: 7

Resumo

Colorectal cancer is a leading cause of death worldwide. The liver is the most common site of distant metastases, and surgery is the only potentially curative treatment, although the recurrence rate following surgery is high. In order to define prognosis after surgery, many histopathological features have been identified in the primary tumour. In turn, pathologists routinely report specific findings to guide oncologists on the decision to recommend adjuvant therapy. In general, the pathological report of resected colorectal liver metastases is limited to confirmation of the malignancy and details regarding the margin status. Most pathological reports of a liver resection for colorectal liver metastasis lack information on other important features that have been reported to be independent prognostic factors. We herein review the evidence to support a more detailed pathological report of the resected liver specimen, with attention to: the number and size of liver metastases; margin size; the presence of lymphatic, vascular, perineural and biliary invasion; mucinous pattern; tumour growth pattern; the presence of a tumour pseudocapsule; and the pathological response to neoadjuvant chemotherapy. In addition, we propose a new protocol for the evaluation of colorectal liver metastasis resection specimens. (AU)

• Processo FAPESP: 15/06551-4 - A relação entre brotamentos tumorais nas metástases hepáticas de câncer colorretal com variáveis anátomo-patológicas e prognóstico
• Beneficiário: Paulo Herman
• Modalidade de apoio: Auxílio à Pesquisa - Regular