Pyridostigmine Improves the Effects of Resistance Exercise Training after Myocardial Infarction in Rats

Autor(es)

Feriani, Daniele J. ^{[1, 2]} ; Coelho-Junior, Helio J. ^[2] ; de Oliveira, Juliana C. M. F. ^[1] ; Delbin, Maria A. ^[3] ; Mostarda, Cristiano T. ^[4] ; Dourado, Paulo M. M. ^[5] ; Caperuto, Erico C. ^[1] ; Irigoyen, Maria C. C. ^[5] ; Rodrigues, Bruno ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Phys Educ, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil

^[4] Univ Fed Maranhao, Fac Phys Educ, Sao Luis - Brazil

^[5] Univ Sao Paulo, Fac Med, Heart Inst InCor, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN PHYSIOLOGY; v. 9, FEB 12 2018.
• Citações Web of Science: 5

Resumo

Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide. Exercise training and pharmacological treatments are important strategies to minimize the deleterious effects of MI. However, little is known about the effects of resistance training combined with pyridostigmine bromide (PYR) treatment on cardiac and autonomic function, as well as on the inflammatory profile after MI. Thus, in the present study, male Wistar rats were randomly assigned into: control (Cont); sedentary infarcted (10; PYR - treated sedentary infarcted rats (Inf+P); infarcted rats undergoing resistance exercise training (Inf+RT); and infarcted rats undergoing PYR treatment plus resistance training (Inf-FRT+P). After 12 weeks of resistance training (15-20 climbs per session, with a 1-min rest between each climb, at a low to moderate intensity, 5 days a week) and/or PYR treatment (0.14 mg/mL of drink water), hemodynamic function, autonomic modulation, and cytokine expressions were evaluated. We observed that 3 months of PYR treatment, either alone or in combination with exercise, can improve the deleterious effects of MI on left ventricle dimensions and function, baroreflex sensitivity, and autonomic parameters, as well as systemic and tissue inflammatory profile. Furthermore, additional benefits in a maximal load test and anti-inflammatory state of skeletal muscle were found when resistance training was combined with PYR treatment. Thus, our findings suggest that the combination of resistance training and PYR may be a good therapeutic strategy since they promote additional benefits on skeletal muscle anti-inflammatory profile after MI. (AU)

• Processo FAPESP: 14/19086-5 - Treinamento físico aeróbico e estimulação colinérgica por brometo de piridostigmina previamente ao infarto do miocárdio: papel na função cardíaca e autonômica
• Beneficiário: Nicolle Martins Carrozzi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/14788-9 - Efeitos do treinamento físico associado à estimulação colinérgica por brometo de piridostigmina previamente e após o infarto do miocárdio: papel na função cardíaca, autonômica e no perfil inflamatório
• Beneficiário: Bruno Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/03908-6 - Adaptações cardíacas e autonômicas ao treinamento físico aeróbico e resistido associado à estimulação colinérgica por brometo de piridostigmina em ratos infartados
• Beneficiário: Daniele Jardim Feriani
• Modalidade de apoio: Bolsas no Brasil - Mestrado