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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

S-nitrosoglutathione-containing chitosan nanoparticles dispersed in Pluronic F-127 hydrogel: Potential uses in topical applications

Texto completo
Autor(es):
Pelegrino, Milena T. [1, 2] ; de Araujo, Daniele R. [1, 2] ; Seabra, Amedea B. [1, 2]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Fed Univ ABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
[2] Fed Univ ABC UFABC, Nanomed Res Unit NANOMED, Santo Andre, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 43, p. 211-220, FEB 2018.
Citações Web of Science: 7
Resumo

The aim of this study was to prepare nitric oxide (NO) releasing nanoparticle/hydrogel with potential uses in topical applications. NO is a signaling molecule in skin. It controls the dermal blood flow, skin defense, and tissue repair. There is an interest for designing topical formulations that release NO/NO donors directly at the desired application site. S-nitrosoglutathione (GSNO), a NO donor, was incorporated into chitosan nanoparticles (CS NPs) (hydrodynamic size of 112.2 +/- 2.22 nm). Free GSNO or GSNO-containing CS NPs were incorporated in Pluronic F-127 (PL) hydrogels. The purpose of this study was to combine the advantages of CS NPs (as a drug delivery system with mucoadhesive properties) and a PL hydrogel, which permits a prolonged contact time for the NO donor on the mucosal/skin surfaces. Rheological measurements were performed to determine the sol-gel transition temperature, the rheological parameters, and the viscosity. The polymeric matrices spontaneously released free NO. GSNO diffusion from the polymeric matrices was evaluated using a diffusion system. The results indicate that the incorporation of GSNO-CS NPs into a PL hydrogel may find important dermatological applications due to their mechanical properties and their ability to release therapeutic and sustained amounts of NO at the desired application site. (AU)

Processo FAPESP: 14/13913-7 - Preparação, caracterização e ensaios biomédicos de sistemas nanoparticulados mono e bimetálicos
Beneficiário:Paula Silvia Haddad Ferreira
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/00393-8 - Nanopartículas poliméricas doadoras de óxido nítrico para aplicações tópicas
Beneficiário:Milena Trevisan Pelegrino
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 16/10347-6 - Nanopartículas contendo S-nitrosotióis: Síntese, caracterização, ensaios de citotoxicidade e aplicações
Beneficiário:Amedea Barozzi Seabra
Linha de fomento: Auxílio à Pesquisa - Regular