Macular and Multifocal PERG and FD-OCT in Preperimetric and Hemifield Loss Glaucoma

Autor(es)

Kreuz, Andre C. ^[1] ; de Moraes, Carlos G. ^[2] ; Hatanaka, Marcelo ^[1] ; Oyamada, Maria K. ^[1] ; Monteiro, Mario L. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch, Dept Ophthalmol & Otolaryngol, Sao Paulo - Brazil

^[2] Columbia Univ, Med Ctr, Dept Ophthalmol, New York, NY - USA

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF GLAUCOMA; v. 27, n. 2, p. 121-132, FEB 2018.
• Citações Web of Science: 1

Resumo

Purpose: To evaluate the ability of macular and multifocal (mf) pattern electroretinogram (PERG) to differentiate preperimetric glaucoma (PG) and glaucoma with hemifield loss (GHL) from controls, to compare the discrimination ability of PERG and fourier-domain optical coherence tomography (FD-OCT), and to assess the relationship between measurements. Patients and Methods: Standard automated perimetry, steady-state and transient PERG and mfPERG measurements were obtained from PG (n=14, 24 eyes), GHL (n=5, 7 eyes), and controls (n=19, 22 eyes). Circumpapillary retinal nerve fiber layer (cpRNFL), fullthickness macula, and segmented macular layer thicknesses on FDOCT were investigated. Measurements were compared using mixed effects linear models. The relationships between measurements and the diagnostic performance of each technology were assessed. Results: Compared with controls, average P50 peak time transient PERG responses were reduced in PG and GHL, whereas average latency and amplitude steady-state and mfPERG responses were abnormal only in GHL. cpRNFL and macular thickness measurements in PG and GHL differed significantly from controls. A significant relationship was found between PERG and most FDOCT or SAP parameters. Partial least squares discriminant analysis revealed that OCT parameters, along with mfPERG and transient PERG parameters had similar ability to discriminate PG and GHL from healthy controls. Conclusions: PERG and OCT parameters may be abnormal, with significant correlations between measurements, in PG eyes. Both technologies may be useful for detection of early glaucoma. (AU)

• Processo FAPESP: 09/50174-0 - Quantificação da perda neural na esclerose múltipla e na neuromielite óptica pela medida da espessura macular e da camada de fibras nervosas da retina com a tomografia de coerência óptica de alta resolução
• Beneficiário: Mário Luiz Ribeiro Monteiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular