Association between GOLGB1 tag-polymorphisms and nonsyndromic cleft palate only in the Brazilian population

Autor(es)

Machado, Renato Assis ^[1] ; Martelli-Junior, Hercilio ^{[2, 3]} ; de Almeida Reis, Silvia Regina ^[4] ; Persuhn, Darlene Camati ^[5] ; Coletta, Ricardo D. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Dent, Dept Oral Diag, BR-13414018 Piracicaba, SP - Brazil

^[2] Univ Estadual Montes Claros, Dent Sch, Stomatol Clin, Montes Claros, MG - Brazil

^[3] Univ Jose Rosario Vellano, Dent Sch, Ctr Rehabil Craniofacial Anomalies, Alfenas, MG - Brazil

^[4] Bahiana Sch Med & Publ Hlth, Dept Basic Sci, Salvador, BA - Brazil

^[5] Univ Fed Paraiba, Mol Biol Dept, Joao Pessoa, Paraiba - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANNALS OF HUMAN GENETICS; v. 82, n. 4, p. 227-231, JUL 2018.
• Citações Web of Science: 1

Resumo

Nonsyndromic oral clefts are common congenital birth defects that exhibit variable prevalence around the world, often influenced by population-dependent genetic predisposition. Few studies have been performed with nonsyndromic cleft palate only (NSCPO), limiting the knowledge of the genetic risk factors related to this type of oral cleft. Genetic variants in golgin subfamily B member 1 (GOLGB1), a gene that is essential for normal murine palatogenesis, were analyzed in this study to establish its potential association with NSCPO risk in the Brazilian population. Five tag-single nucleotide polymorphisms (SNPs) of GOLGB1 (rs1169, rs7153, rs9968051, rs9819530, and rs6794341), which capture the majority of alleles spanning within gene, were genotyped in a case-control study with 270 patients with NSCPO and 284 unrelated healthy controls. The samples were also genotyped for 40 biallelic polymorphic markers to characterize the genetic ancestry. After adjustment for co-variants, the GOLGB1 tag-SNPs and the haplotypes formed by those SNPs were not significantly associated with NSCPO in this Brazilian case-control cohort. Our results suggest that common polymorphisms of GOLGB1 are not associated NSCPO susceptibility in the Brazilian population. (AU)

• Processo FAPESP: 16/02667-0 - Interações entre Fatores Ambientais e Polimorfismos em Genes Relacionados ao Estresse Oxidativo na Suscetibilidade das Fissuras Orais Não-Sindrômicas
• Beneficiário: Ricardo Della Coletta
• Modalidade de apoio: Auxílio à Pesquisa - Regular