Remineralizing effect of a fluoridated gel containing sodium hexametaphosphate: An in vitro study

Autor(es)

Castro Goncalves, Francyenne Maira ^[1] ; Botazzo Delbem, Alberto Carlos ^[1] ; Pessan, Juliano Pelim ^[1] ; Nunes, Gabriel Pereira ^[1] ; Emerenciano, Nayara Goncalves ^[1] ; Gonzales Garcia, Luhana Santos ^[1] ; Baez Quintero, Liliana Carolina ^[1] ; Neves, Jose Guilherme ^[1] ; Danelon, Marcelle ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Sch Dent, Dept Pediat Dent & Publ Hlth, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ORAL BIOLOGY; v. 90, p. 40-44, JUN 2018.
• Citações Web of Science: 1

Resumo

Objectives: To evaluate in vitro the effect of neutral pH topical gels with reduced fluoride concentration (F), supplemented or not with sodium hexametaphosphate (HMP) on the remineralization of dental enamel, using a pH-cycling model. Materials and methods Bovine enamel blocks with caries-like lesions were randomly treated with five gels (n = 24/group): without F/HMP (Placebo); 4500 ppm F (4500F), 4500F plus 9% HMP (4500F + HMP); 9000 ppm F (9000F); and 12,300 ppm F (Acid gel). After pH-cycling, the percentage of surface hardness recovery (%SHR), integrated loss of subsurface hardness (AKHN), and concentrations of loosely-(CaF2) and firmly-bound (FA) fluoride formed and retained in/on enamel were determined. The results were analyzed by ANOVA followed by the Student-Newman-Keuls test (p < 0.001). Results: The 4500F + HMP gel promoted the highest %SHR among all groups; the lowest AKHN was achieved by 4500F + HMP and Acid gel, without significant differences between these. The Acid gel group presented the highest CaF2 and FA formed and retained on/in enamel (p < 0.001). Conclusion: Based on the present results, the addition of 9% sodium hexametaphosphate to a gel with reduced fluoride concentration (4500F) was able to significantly enhance the remineralization of artificial carious lesions in vitro when compared to 4500F, reaching protective levels similar to an acidic formulation with 3-fold higher fluoride concentration. (AU)

• Processo FAPESP: 14/06676-9 - Efeito da adição de nanopartículas de hexametafosfato de sódio em dentifrícios fluoretados sobre a desmineralização dentária: estudo in vitro
• Beneficiário: Gabriel Pereira Nunes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica