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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Role of ventral medullary catecholaminergic neurons for respiratory modulation of sympathetic outflow in rats

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Autor(es):
Moraes, Davi J. A. [1] ; Bonagamba, Leni G. H. [1] ; da Silva, Melina P. [1] ; Paton, Julian F. R. [2, 3] ; Machado, Benedito H. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Bristol, Biomed Sci, Sch Physiol Pharmacol & Neurosci, Bristol, Avon - England
[3] Univ Auckland, Dept Physiol, Fac Med & Hlth Sci, Auckland - New Zealand
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 7, DEC 4 2017.
Citações Web of Science: 4
Resumo

Sympathetic activity displays rhythmic oscillations generated by brainstem inspiratory and expiratory neurons. Amplification of these rhythmic respiratory-related oscillations is observed in rats under enhanced central respiratory drive or during development of neurogenic hypertension. Herein, we evaluated the involvement of ventral medullary sympatho-excitatory catecholaminergic C1 neurons, using inhibitory Drosophila allatostatin receptors, for the enhanced expiratory-related oscillations in sympathetic activity in rats submitted to chronic intermittent hypoxia (CIH) and following activation of both peripheral (hypoxia) and central chemoreceptors (hypercapnia). Pharmacogenetic inhibition of C1 neurons bilaterally resulted in reductions of their firing frequency and amplitude of inspiratory-related sympathetic activity in rats in normocapnia, hypercapnia or after CIH. In contrast, hypercapnia or hypoxia-induced enhanced expiratory-related sympathetic oscillations were unaffected by C1 neuronal inhibition. Inhibition of C1 neurons also resulted in a significant fall in arterial pressure and heart rate that was similar in magnitude between normotensive and CIH hypertensive rats, but basal arterial pressure in CIH rats remained higher compared to controls. C1 neurons play a key role in regulating inspiratory modulation of sympathetic activity and arterial pressure in both normotensive and CIH hypertensive rats, but they are not involved in the enhanced late-expiratory-related sympathetic activity triggered by activation of peripheral or central chemoreceptors. (AU)

Processo FAPESP: 15/01073-7 - Caracterização eletrofisiológica de motoneurônios expiratórios de ratos submetidos a hipóxia mantida
Beneficiário:Melina Pires da Silva Moraes
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/10484-5 - Caracterização eletrofisiológica e molecular dos neurônios envolvidos na geração do ritmo e do padrão respiratório de ratos durante o desenvolvimento pós-natal
Beneficiário:Davi José de Almeida Moraes
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 13/06077-5 - Alterações nas redes neurais envolvidas na geração e controle das atividades simpática e respiratória em diferentes modelos experimentais de hipóxia
Beneficiário:Benedito Honorio Machado
Linha de fomento: Auxílio à Pesquisa - Temático