Ilheus and Saint Louis encephalitis viruses elicit cross-protection against a lethal Rocio virus challenge in mice

Autor(es):Mostrar menos -

Amarilla, Alberto Anastacio ^{[1, 2]} ; Fumagalli, Marcilio Jorge ^[3] ; Figueiredo, Mario Luis ^[1] ; Lima-Junior, Djalma S. ^[4] ; Santos-Junior, Nilton Nascimento ^[5] ; Alfonso, Helda Liz ^[1] ; Lippi, Veronica ^[1] ; Trabuco, Amanda Cristina ^[1] ; Lauretti, Flavio ^[3] ; Muller, Vanessa Danielle ^[1] ; Colon, David F. ^[6] ; Luiz, Joao P. M. ^[6] ; Suhrbier, Andreas ^{[7, 2]} ; Setoh, Yin Xiang ^[2] ; Khromykh, Alexander A. ^[2] ; Moraes Figueiredo, Luiz Tadeu ^[3] ; Aquino, Victor Hugo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Lab Virol, Ribeirao Preto, SP - Brazil

^[2] Univ Queensland, Australian Infect Dis Res Ctr, Sch Chem & Mol Biosci, St Lucia, Qld - Australia

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Ribeirao Preto, SP - Brazil

^[5] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Ribeirao Preto, SP - Brazil

^[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Lab Inflammat & Pain, Dept Immunol, Ribeirao Preto, SP - Brazil

^[7] QIMR Berghofer Med Res Inst, Brisbane, Qld - Australia

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 13, n. 6 JUN 13 2018.
• Citações Web of Science: 4

Resumo

Rocio virus (ROCV) was the causative agent of an unprecedented outbreak of encephalitis during the 1970s in the Vale do Ribeira, Sao Paulo State, in the Southeast region of Brazil. Surprisingly, no further cases of ROCV infection were identified after this outbreak; however, serological surveys have suggested the circulation of ROCV among humans and animals in different regions of Brazil. Cross-protective immunity among flaviviruses is well documented; consequently, immunity induced by infections with other flaviviruses endemic to Brazil could potentially be responsible for the lack of ROCV infections. Herein, we evaluated the cross-protection mediated by other flaviviruses against ROCV infection using an experimental C57BU6 mouse model. Cross-protection against ROCV infection was observed when animals had prior exposure to Ilheus virus or Saint Louis encephalitis virus, suggesting that cross-reactive anti-flavivirus antibodies may limit ROCV disease outbreaks. (AU)

• Processo FAPESP: 14/02438-6 - Estudos com Bunyaviridae causadores de doença
• Beneficiário: Luiz Tadeu Moraes Figueiredo
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/08778-8 - Análise da participação da proteína e na neuroinvassividade e neurovirulência do Vírus Rocio em modelo animal
• Beneficiário: Alberto Anastacio Amarilla Ortiz
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/15548-4 - Estudo sobre vírus transmitidos por artrópodes e roedores: diagnóstico e proteção cruzada
• Beneficiário: Victor Hugo Aquino Quintana
• Linha de fomento: Auxílio à Pesquisa - Regular