Anthropometric measures of central adiposity are highly concordant with predictors of cardiovascular disease risk in HIV patients

Autor(es)

Beraldo, Rebeca A. ^[1] ; Meliscki, Gabriela C. ^[2] ; Silva, Bruna R. ^[2] ; Navarro, Anderson M. ^[1] ; Bollela, Valdes R. ^[1] ; Schmidt, Andre ^[1] ; Foss-Freitas, Maria C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Nutr & Metab Grad Course, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF CLINICAL NUTRITION; v. 107, n. 6, p. 883-893, JUN 2018.
• Citações Web of Science: 4

Resumo

Background: Body fat redistribution and metabolic abnormalities found in HIV patients receiving highly active antiretroviral therapy (HAART) contribute to an atherogenic profile, increasing cardiovascular disease risk. Objective: We aimed to evaluate adiposity measures/indexes and propose cutoffs associated with predictors of cardiovascular disease risk in HIV patients on HAART. Design: To evaluate cardiovascular disease risk in this crosssectional study, we conducted electrocardiogram exams and stress electrocardiography, measured the ankle brachial index and blood pressure arterial hypertension, conducted lipid biochemical tests, and measured blood glucose. We measured circumferences {[}waist (WC), hip, thigh, calf, neck, trunk] and skinfold thicknesses (biceps, triceps, subscapular, suprailiac), conducted bioelectrical impedance analysis (BIA), and calculated indexes {[}body mass index, waist-to-hip ratio, waist-to-thigh ratio, waist-to-calf ratio, waist-to-height ratio (WHtR), trunk-to-arm ratio, body mass index corrected for body fat mass, Body Adiposity Index, comcity index, body shape index, fat mass (percentage), and phase angle]. For evaluating the performance of all adiposity measures/indexes, we used receiver operating characteristic (ROC) curves. Results: Measures of central adiposity WC and WHtR showed the best performances-WC area under the curve (AUC) for men: 0.83 (95% Cl: 0.78, 0.89; P < 0.05); WC AUC for women: 0.86 (95% CI: 0.81, 0.91; P < 0.05); WHtR AUC for men: 0.83 (95% CI: 0.78, 0.88; P < 0.05); and WHtR AUC for women: 0.85 (95% CI: 0.80, 0.91; P < 0.05). All adiposity measures/indexes presented different cutoffs from those proposed for the HIV seronegative population. The cutoffs for WC were 87.75 cm (sensitivity: 82.2%; specificity: 75.5%) for men and 90.5 cm (sensitivity: 84.0%; specificity: 73.0%) for women. Conclusions: The measures/indexes of central adiposity presented excellent associations with predictors of cardiovascular disease risk, and the use of the cutoffs proposed in the present study aims to contribute to the early identification of increasing risk of cardiovascular diseases, enabling interventions. This trial was registered at the Brazilian clinical trials registry Registro brasileiro de ensaios clmicos (Rebec) as RBR-9rcxbq. Am J Clin Nutr 2018;107:883-893. (AU)

• Processo FAPESP: 16/14698-8 - Avaliação de índices de adiposidade e ângulo de fase para predizer alterações metabólicas e risco cardiovascular em pacientes soropositivos para HIV
• Beneficiário: Maria Cristina Foss de Freitas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/23287-3 - Avaliação e proposta de pontos de corte para índices de adiposidade para predizer risco cardiovascular em pacientes soropositivos para HIV em terapia antirretroviral
• Beneficiário: Rebeca Antunes Beraldo
• Modalidade de apoio: Bolsas no Brasil - Doutorado