Transcription Blockage Leads to New Beginnings

Autor(es)

Andrade-Lima, Leonardo C. ^{[1, 2, 3]} ; Veloso, Artur ^{[4, 2, 3, 5]} ; Ljungman, Mats ^{[6, 2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil

^[2] Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 - USA

^[3] Univ Michigan, Sch Med, Translat Oncol Program, Ann Arbor, MI 48109 - USA

^[4] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 - USA

^[5] Novartis Inst Biomed Sci, Cambridge, MA 02139 - USA

^[6] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: BIOMOLECULES; v. 5, n. 3, p. 1600-1617, SEP 2015.
• Citações Web of Science: 4

Resumo

Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes. (AU)

• Processo FAPESP: 09/50036-6 - Interação entre vias de reparo de DNA e sinalização em resposta a danos através de silenciamento gênico
• Beneficiário: Leonardo Carmo de Andrade Lima
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto