Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transcription Blockage Leads to New Beginnings

Full text
Author(s):
Andrade-Lima, Leonardo C. [1, 2, 3] ; Veloso, Artur [4, 2, 3, 5] ; Ljungman, Mats [6, 2, 3]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
[2] Univ Michigan, Sch Med, Dept Radiat Oncol, Ann Arbor, MI 48109 - USA
[3] Univ Michigan, Sch Med, Translat Oncol Program, Ann Arbor, MI 48109 - USA
[4] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 - USA
[5] Novartis Inst Biomed Sci, Cambridge, MA 02139 - USA
[6] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 - USA
Total Affiliations: 6
Document type: Review article
Source: BIOMOLECULES; v. 5, n. 3, p. 1600-1617, SEP 2015.
Web of Science Citations: 4
Abstract

Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes. (AU)