Inconsistent relation of nonlinear heart rate variability indices to increasing vagal tone in healthy humans

Autor(es)

Cepeda, Felipe X. ^{[1, 2]} ; Lapointe, Matthew ^[1] ; Tan, Can Ozan ^{[1, 3]} ; Taylor, J. Andrew ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Spaulding Rehabil Hosp, Cardiovasc Res Lab, 1575 Cambridge St, Cambridge, MA 02138 - USA

^[2] Univ Sao Paulo, Hosp Clin, Fac Med, Heart Inst InCor HCFMUSP, Sao Paulo - Brazil

^[3] Harvard Med Sch, Dept Phys Med & Rehabil, Boston, MA - USA

• Tipo de documento: Artigo Científico
• Fonte: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 213, p. 1-7, SEP 2018.
• Citações Web of Science: 2

Resumo

Background: Prior work has found that linear heart rate variability (HRV) indices do not accurately reflect cardiac vagal control, and nonlinear indices of HRV have been proposed as alternative tools that may better capture cardiac vagal effects. We used progressive low dose atropine to induce changes in cardiac vagal tone to test the hypotheses that nonlinear HRV indices accurately reflect cardiac vagal control, and that their changes in response to low dose atropine correlate with those in RR interval. Methods: Changes in RR interval and HRV indices during intravenous injections of saline (control) and 6 cumulative doses of atropine (from 1.4 to 7.2 mu g/kg) during controlled breathing at 15 breaths per minute were assessed in 14 young healthy individuals. Results: As expected, low dose atropine increased average RR interval (vagotonic effect). There was no strong association between vagotonic changes in RR interval and the majority of nonlinear HRV indices, either within or among subjects. Conclusions: These data suggest an inconsistent relationship between responses of nonlinear HRV indices and RR interval to changes in cardiac vagal tone. Therefore, nonlinear HRV indices may not be reliable indices of cardiac vagal control in healthy humans. (AU)

• Processo FAPESP: 16/16831-7 - Marcadores metabólicos/inflamatórios e balanço simpato-vagal em pacientes com síndrome metabólica e apneia obstrutiva do sono: efeito da dieta hipocalórica e treinamento físico
• Beneficiário: Felipe Xerez Cepêda Fonseca
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado