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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Inconsistent relation of nonlinear heart rate variability indices to increasing vagal tone in healthy humans

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Author(s):
Cepeda, Felipe X. [1, 2] ; Lapointe, Matthew [1] ; Tan, Can Ozan [1, 3] ; Taylor, J. Andrew [1, 3]
Total Authors: 4
Affiliation:
[1] Spaulding Rehabil Hosp, Cardiovasc Res Lab, 1575 Cambridge St, Cambridge, MA 02138 - USA
[2] Univ Sao Paulo, Hosp Clin, Fac Med, Heart Inst InCor HCFMUSP, Sao Paulo - Brazil
[3] Harvard Med Sch, Dept Phys Med & Rehabil, Boston, MA - USA
Total Affiliations: 3
Document type: Journal article
Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 213, p. 1-7, SEP 2018.
Web of Science Citations: 2
Abstract

Background: Prior work has found that linear heart rate variability (HRV) indices do not accurately reflect cardiac vagal control, and nonlinear indices of HRV have been proposed as alternative tools that may better capture cardiac vagal effects. We used progressive low dose atropine to induce changes in cardiac vagal tone to test the hypotheses that nonlinear HRV indices accurately reflect cardiac vagal control, and that their changes in response to low dose atropine correlate with those in RR interval. Methods: Changes in RR interval and HRV indices during intravenous injections of saline (control) and 6 cumulative doses of atropine (from 1.4 to 7.2 mu g/kg) during controlled breathing at 15 breaths per minute were assessed in 14 young healthy individuals. Results: As expected, low dose atropine increased average RR interval (vagotonic effect). There was no strong association between vagotonic changes in RR interval and the majority of nonlinear HRV indices, either within or among subjects. Conclusions: These data suggest an inconsistent relationship between responses of nonlinear HRV indices and RR interval to changes in cardiac vagal tone. Therefore, nonlinear HRV indices may not be reliable indices of cardiac vagal control in healthy humans. (AU)

FAPESP's process: 16/16831-7 - Metabolic/inflammatory markers and sympatho-vagal balance in patients with metabolic syndrome and obstructive sleep apnea: effect of hypocaloric diet and exercise training
Grantee:Felipe Xerez Cepêda Fonseca
Support Opportunities: Scholarships abroad - Research Internship - Doctorate