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Impact of Regular Physical Activity on Adipocytokines and Cardiovascular Characteristics in Spinal Cord-Injured Subjects

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Autor(es):
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Schreiber, Roberto [1] ; Souza, Cristiane M. [1] ; Paim, Layde R. [1] ; de Rossi, Guilherme [1] ; Matos-Souza, Jose R. [1] ; Costa e Silva, Anselmo de A. [2] ; Faria, Fernando R. [2] ; Azevedo, Eliza R. [3] ; Alonso, Karina C. [3] ; Sposito, Andrei C. [1] ; Cliquet Jr, Alberto ; Gorla, I, Jose ; Nadruz Jr, Wilson
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Internal Med, Campinas, SP - Brazil
[2] I, Univ Estadual Campinas, Sch Phys Educ, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Dept Orthoped, Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION; v. 99, n. 8, p. 1561-1567, AUG 2018.
Citações Web of Science: 0
Resumo

Objective: To investigate the relationship of carotid artery intima-media thickness (IMT) and cardiac structure and function with adipocytokines in sedentary (S-SCI) and physically active (PA-SCI) subjects with spinal cord injury (SCI). Design: Cross-sectional observational study. Setting: Academic medical center. Participants: Men with chronic (>1y) SCI (N=41; 16 S-SCI, 25 PA-SCI) were evaluated. S-SCI subjects did not perform labor that required physical effort, recreational physical activity, or sports, while PA-SCI subjects included competing athletes who were regularly performing adapted sports. Interventions: Not applicable. Main Outcome Measures: Clinical, laboratory, carotid ultrasonography, and echocardiography analysis. Plasma leptin, adiponectin, and plasminogen activating inhibitor-1 (PAI-1) levels were determined. Results: PA-SCI subjects had similar levels of adipocytokines, but lower carotid IMT and carotid IMT/diameter, and better left ventricular diastolic function than S-SCI participants. Bivariate analysis showed that adiponectin was inversely correlated with triglycerides (r=.85, P<.001), low-density lipoprotein cholesterol (r=.57, P<.05), and carotid IMT/diameter (r=.56, P<.05) in S-SCI but not in PA-SCI participants. Additionally, the leptin-adiponectin ratio showed a direct correlation with triglycerides (r=.84, P<.001) and low-density lipoprotein cholesterol (r=.53, P<.05) in S-SCI but not in PA-SCI individuals. By contrast, the studied adipocytokines did not correlate with cardiac structure and function in PA-SCI and S-SCI participants. Conclusions: Lower adiponectin levels and higher leptin-adiponectin ratio are related to adverse vascular and/or metabolic characteristics in individuals with SO. This relationship, however, appears to be mitigated by regular physical activity. (C) 2018 by the American Congress of Rehabilitation Medicine (AU)

Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
Beneficiário:Licio Augusto Velloso
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs