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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of Regular Physical Activity on Adipocytokines and Cardiovascular Characteristics in Spinal Cord-Injured Subjects

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Author(s):
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Schreiber, Roberto [1] ; Souza, Cristiane M. [1] ; Paim, Layde R. [1] ; de Rossi, Guilherme [1] ; Matos-Souza, Jose R. [1] ; Costa e Silva, Anselmo de A. [2] ; Faria, Fernando R. [2] ; Azevedo, Eliza R. [3] ; Alonso, Karina C. [3] ; Sposito, Andrei C. [1] ; Cliquet Jr, Alberto ; Gorla, I, Jose ; Nadruz Jr, Wilson
Total Authors: 13
Affiliation:
[1] Univ Estadual Campinas, Dept Internal Med, Campinas, SP - Brazil
[2] I, Univ Estadual Campinas, Sch Phys Educ, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Dept Orthoped, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION; v. 99, n. 8, p. 1561-1567, AUG 2018.
Web of Science Citations: 0
Abstract

Objective: To investigate the relationship of carotid artery intima-media thickness (IMT) and cardiac structure and function with adipocytokines in sedentary (S-SCI) and physically active (PA-SCI) subjects with spinal cord injury (SCI). Design: Cross-sectional observational study. Setting: Academic medical center. Participants: Men with chronic (>1y) SCI (N=41; 16 S-SCI, 25 PA-SCI) were evaluated. S-SCI subjects did not perform labor that required physical effort, recreational physical activity, or sports, while PA-SCI subjects included competing athletes who were regularly performing adapted sports. Interventions: Not applicable. Main Outcome Measures: Clinical, laboratory, carotid ultrasonography, and echocardiography analysis. Plasma leptin, adiponectin, and plasminogen activating inhibitor-1 (PAI-1) levels were determined. Results: PA-SCI subjects had similar levels of adipocytokines, but lower carotid IMT and carotid IMT/diameter, and better left ventricular diastolic function than S-SCI participants. Bivariate analysis showed that adiponectin was inversely correlated with triglycerides (r=.85, P<.001), low-density lipoprotein cholesterol (r=.57, P<.05), and carotid IMT/diameter (r=.56, P<.05) in S-SCI but not in PA-SCI participants. Additionally, the leptin-adiponectin ratio showed a direct correlation with triglycerides (r=.84, P<.001) and low-density lipoprotein cholesterol (r=.53, P<.05) in S-SCI but not in PA-SCI individuals. By contrast, the studied adipocytokines did not correlate with cardiac structure and function in PA-SCI and S-SCI participants. Conclusions: Lower adiponectin levels and higher leptin-adiponectin ratio are related to adverse vascular and/or metabolic characteristics in individuals with SO. This relationship, however, appears to be mitigated by regular physical activity. (C) 2018 by the American Congress of Rehabilitation Medicine (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC